m6A修饰阅读蛋白YTH在结直肠癌中的机制研究进展

doi:10.11904/j.issn.1002-3070.2023.02.014

实用肿瘤学杂志 ›› 2023, Vol. 37 ›› Issue (2): 170-174.doi: 10.11904/j.issn.1002-3070.2023.02.014

m6A修饰阅读蛋白YTH在结直肠癌中的机制研究进展

陈丽名综述, 夏敏审校

南京医科大学附属无锡人民医院消化内科(无锡 214023)

收稿日期:2022-10-19 修回日期:2023-04-11 发布日期:2023-05-30
通讯作者: 夏敏,E-mail:xmzb1013@163.com
作者简介:陈丽名,女,(1995-),硕士研究生,从事消化道肿瘤机制的研究。
基金资助:
无锡市卫生健康委重大项目(编号:Z202115)

Research progress in the mechanism of m6A-modified reading protein YTH in colorectal cancer

CHEN Liming, XIA Min

Department of Gastroenterology,The Affiliated Wuxi People′s Hospital of Nanjing Medical University,Wuxi 214023,China

Received:2022-10-19 Revised:2023-04-11 Published:2023-05-30

摘要/Abstract

摘要： N6-甲基腺苷(N6-methyladenosine,m6A)是真核生物mRNA和长链非编码RNA(lncRNAs)中最丰富的内部化学修饰,其过程由甲基转移酶、去甲基化酶和阅读蛋白参与完成,并依赖三者进行动态调控。其中YT521-B同源域(YT521-B homology,YTH)蛋白是一类成熟的m6A阅读蛋白,它可以特异性地识别含有m6A的RNA并介导其行使功能,与多种肿瘤发生发展有关。然而,关于YTH蛋白在结直肠癌中的作用知之甚少。本文综述了YTH蛋白在结直肠癌中的相关通路机制,为结直肠癌个性化治疗提供借鉴。

关键词: YT521-B同源域蛋白, m6A阅读蛋白, 结直肠癌

Abstract: N6-methyladenosine(m6A)is the most abundant internal chemical modifications in eukaryotic mRNA and long non-coding RNAs(lncRNAs),and its process is controlled by methyltransferase,demethylase and reader proteins are involved in the completion and rely on the three dynamic regulation.Among them,the YT521-B homology domain(YTH)protein is a kind of mature m6A reading protein,which can specifically recognize m6A-containing RNA and mediate its function,and is related to the occurrence and development of various tumors.However,little is known about the role of YTH proteins in colorectal cancer.This article reviews the structure,function and related pathway mechanism of the YTH protein in colorectal cancer,so as to provide the reference for the personalized treatment for colorectal cancer.

Key words: YT521-B homology domain protein, M6A readers protein, Colorectal cancer

中图分类号:

R735

陈丽名, 夏敏. m6A修饰阅读蛋白YTH在结直肠癌中的机制研究进展[J]. 实用肿瘤学杂志, 2023, 37(2): 170-174.

CHEN Liming, XIA Min. Research progress in the mechanism of m6A-modified reading protein YTH in colorectal cancer[J]. Journal of Practical Oncology, 2023, 37(2): 170-174.

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http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2023/V37/I2/170

参考文献

1 Boccaletto P,Stefaniak F,Ray A,et al.MODOMICS:a database of RNA modification pathways.2021 update[J].Nucleic Acids Res,2022,50(1):231-235.
2 Zhang H,Shi X,Huang T,et al.Dynamic landscape and evolution of m6A methylation in human[J].Nucleic Acids Res,2020,48(11):6251-6264.
3 Meyer KD,Jaffrey SR.Rethinking m6A readers,writers,and erasers[J].Annu Rev Cell Dev Biol,2017,33(1):319-342.
4 Shi R,Ying S,Li Y,et al.Linking the YTH domain to cancer:the importance of YTH family proteins in epigenetics[J].Cell Death Dis,2021,12(4):346.
5 Xu C,Wang X,Liu K,et al.Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain[J].Nat Chem Biol,2014,10(11):927-929.
6 Patil DP,Pickering BF,Jaffrey SR.Reading m6A in the transcriptome:m6A-binding proteins[J].Trends Cell Biol,2018,28(2):113-127.
7 Wang X,Zhao BS,Roundtree IA,et al.N6-methyladenosine modulates messenger RNA translation efficiency[J].Cell,2015,161(6):1388-1399.
8 Nguyen Ba AN,Yeh BJ,van Dyk D,et al.Proteome-wide discovery of evolutionary conserved sequences in disordered regions[J].Sci Signal,2012,5(215):1.
9 Zaccara S,Jaffrey SR.A unified model for the function of YTHDF proteins in regulating m6A-modified mRNA[J].Cell,2020,181(7):1582-1595.
10 Li Y,Bedi RK,Moroz-Omori EV,et al.Structural and dynamic insights into redundant function of YTHDF proteins[J].J Chem Inf Model,2020,60(12):5932-5935.
11 Berlivet S,Scutenaire J,Deragon JM,et al.Readers of the m6A epitranscriptomic code[J].Biochim Biophys Acta Gene Regul Mech,2019,1862(3):329-342.
12 Li A,Chen YS,Ping XL,et al.Cytoplasmic m6A reader YTHDF3 promotes mRNA translation[J].Cell Res,2017,27(3):444-447.
13 Liu J,Dou X,Chen C,et al.N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription[J].Science,2020,367(6477):580-586.
14 Roundtree IA,Luo GZ,Zhang Z,et al.YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs[J].Elife,2017,6:e31311.
15 Kretschmer J,Rao H,Hackert P,et al.The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5′-3′exoribonuclease XRN1[J].RNA,2018,24(10):1339-1350.
16 Nishizawa Y,Konno M,Asai A,et al.Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer[J].Oncotarget,2018,9(7):7476-7486.
17 Bai Y,Yang C,Wu R,et al.YTHDF1 regulates tumorigenicity and cancer stem cell-like activity in human colorectal carcinoma[J].Front Oncol,2019,9:332.
18 Han B,Yan S,Wei S,et al.YTHDF1-mediated translation amplifies Wnt-driven intestinal stemness[J].EMBO Rep,2020,21(4):e49229.
19 Wang S,Yuan B,Wang Y,et al.Clinicopathological and prognostic significance of PD-L1 expression in colorectal cancer:a meta-analysis[J].Int J Colorectal Dis,2021,36(1):117-130.
20 Liu YZ,Han DT,Shi DR,et al.Pathological significance of abnormal recepteur d′origine nantais and programmed death ligand 1 expression in colorectal cancer[J].World J Gastrointest Oncol,2020,12(11):1216-1236.
21 Gao Y,Nihira NT,Bu X,et al.Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy[J].Nat Cell Biol,2020,22(9):1064-1075.
22 余诗俊,栗丽,窦宁,等.m6A甲基化修饰调控结直肠癌细胞中PD-L1表达[J].兰州大学学报(医学版),2021,47(1):47-51.
23 Liu X,Liu L,Dong Z,et al.Expression patterns and prognostic value of m(6)A-related genes in colorectal cancer[J].Am J Transl Res,2019,11(7):3972-3991.
24 Ni W,Yao S,Zhou Y,et al.Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3[J].Mol Cancer,2019,18(1):143.
25 Chen RX,Chen X,Xia LP,et al.N(6)-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis[J].Nat Commun,2019,10(1):4695.
26 Wu J,Wang Y,Xu X,et al.Transcriptional activation of FN1 and IL11 by HMGA2 promotes the malignant behavior of colorectal cancer[J].Carcinogenesis,2016,37(5):511-521.
27 Tanabe A,Tanikawa K,Tsunetomi M,et al.RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated[J].Cancer Lett,2016,376(1):34-42.
28 Nagaraju GP,Bramhachari PV,Raghu G,et al.Hypoxia inducible factor-1α:Its role in colorectal carcinogenesis and metastasis[J].Cancer Lett,2015,366(1):11-18.

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[10]	朱公建, 朱奕潼, 丁高恒, 王宏宗, 杜美霞, 刘玉琴. 2009—2015年甘肃省肿瘤登记地区结直肠癌流性特征及变化趋势分析[J]. 实用肿瘤学杂志, 2021, 35(3): 212-217.
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[13]	赵仁成, 林子棠, 余卫军, 雷林, 刘峥, 徐英, 郭艳芳, 彭绩. 2017—2019年深圳市宝安区40~74岁常住居民五癌风险流行状况分析[J]. 实用肿瘤学杂志, 2020, 34(4): 315-320.
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[15]	朱晓云, 张亚宁, 马碧萍. 1980—2018年上海市金山区结直肠癌死亡水平及其所致早死概率的趋势分析[J]. 实用肿瘤学杂志, 2020, 34(3): 198-202.

m6A修饰阅读蛋白YTH在结直肠癌中的机制研究进展

Research progress in the mechanism of m6A-modified reading protein YTH in colorectal cancer

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