植物化学物在肿瘤免疫治疗中的研究进展

doi:10.11904/j.issn.1002-3070.2025.05.010

实用肿瘤学杂志 ›› 2025, Vol. 39 ›› Issue (5): 428-432.doi: 10.11904/j.issn.1002-3070.2025.05.010

植物化学物在肿瘤免疫治疗中的研究进展

张轩¹, 李娟², 方传丰¹, 田虹¹ 综述, 刘家仁^1,3 审校

1.哈尔滨医科大学附属第四医院检验科(哈尔滨 150001);
2.云南省阜外心血管病医院检验科;
3.黑龙江省分子医学工程技术研究中心

收稿日期:2025-02-12 修回日期:2025-06-04 出版日期:2025-10-28 发布日期:2025-11-07
通讯作者: 刘家仁,E-mail:Jiarenliu@hrbmu.edu.cn
作者简介:张轩,男,(2000—),硕士研究生,从事植物化学物调节免疫方面的研究。
基金资助:
国家自然科学基金项目(编号:82172580)

Research progress of phytochemicals in tumor immunotherapy

ZHANG Xuan¹, LI Juan², FANG Chuanfeng¹, TIAN Hong¹, LIU Jiaren^1,3

1. Department of Laboratory Diagnosis,The Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China;
2. Department of Laboratory Medicine,Fuwai Cardiovascular Disease Hospital,Yunnan Province;
3. Heilongjiang Molecular Medicine Engineering Technology Research Center

Received:2025-02-12 Revised:2025-06-04 Online:2025-10-28 Published:2025-11-07

摘要/Abstract

摘要： 近年来,恶性肿瘤的发病率与死亡率呈逐年上升趋势,对全球公共卫生构成了严峻挑战。与传统治疗手段不同,肿瘤免疫治疗通过激活人体自身的免疫系统来对抗肿瘤,具有副作用小、疗效持久及靶向性强等显著优势。然而,免疫治疗亦存在不良反应较多以及治疗费用高昂等问题。为了提升免疫治疗的疗效,一些植物化学物被用作调节剂引入免疫治疗领域。这些植物化学物不仅能增强肿瘤细胞对免疫细胞的敏感性,还能降低免疫检查点蛋白的表达水平。因此,本文对肿瘤免疫治疗中发挥重要作用的植物化学物及其相关作用机制进行综述。

关键词: 植物化学物, 肿瘤, 免疫治疗

Abstract: In recent years,the incidence and mortality of malignant tumors have been increasing year by year,becoming a serious challenge to global public health.Unlike traditional treatment methods,tumor immunotherapy activates the body's own immune system to against tumors,and has significant advantage such as minimal side effects,long-lasting efficacy,and strong targeting.However,immunotherapy also has issues such as frequent adverse reactions and high treatment costs.In order to enhance the efficacy of immunotherapy,some phytochemicals are used in the field of immunotherapy as modulators.These phytochemicals not only increase the sensitivity of tumor cells to immune cells,but also reduce the expression of immune checkpoint proteins.Therefore,this article provides a review of phytochemicals that play an important role in tumor immunotherapy and their related mechanisms of action.

Key words: phytochemicals, tumor, immunotherapy

中图分类号:

张轩, 李娟, 方传丰, 田虹, 刘家仁. 植物化学物在肿瘤免疫治疗中的研究进展[J]. 实用肿瘤学杂志, 2025, 39(5): 428-432.

ZHANG Xuan, LI Juan, FANG Chuanfeng, TIAN Hong, LIU Jiaren. Research progress of phytochemicals in tumor immunotherapy[J]. Journal of Practical Oncology, 2025, 39(5): 428-432.

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植物化学物在肿瘤免疫治疗中的研究进展

Research progress of phytochemicals in tumor immunotherapy

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