肿瘤干细胞潜在标志物DCLK1在消化道恶性肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2015.05.016

Abstract

Abstract: The discovery and application of cancer stem cell markers have very important significance on tumor treatment and prevention.DCLK1 is discovered only in the cancer stem cell marker but not nomal stem cells for the first time.Some studies have shown that DCLK1 expression was detectded in gastrointestinal cancer,esophageal cancer,bile duct carcinoma and glioma.The expression of DCLK1 in tumor is closely related to tumor development,progression,and recurrenceand migration.Although DCLK1 remain to be known as cancer stem cell marker,it provides a new developing prospectives for tumor targeting specific treatment.

Key words: DCLK1, Neoplastic stem cells, Gastrointestinal tumor, Targeted therapy, Prognosis

CLC Number:

R73.5

LV Fulian, GAO Xiang, JIN Aishun. Functional characteristic research progress of DCLK1 as a potential biomarker in cancer stem cells for gastrointestinal onalignancies[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(5): 458-461.

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Functional characteristic research progress of DCLK1 as a potential biomarker in cancer stem cells for gastrointestinal onalignancies

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