PD-L1的表达与妇科恶性肿瘤预后关系的研究进展

doi:10.11904/j.issn.1002-3070.2018.05.017

Abstract

Abstract: Programmed death protein 1(PD-1)is a major inhibitory receptor in T cells.Programmed death ligand-1(PD-L1,also known as B7-H1)is widely expressed in epithelial cells and endothelial cells of many organs such as heart,liver,kidney and lung.Tumor microenvironment in tumorigenesis causes invasive T cells to express PD-1,and PD-L1 is up-regulated in tumor cells,which binds to the PD-1 receptor,resulting in sustained PD-1 pathway in tumor microenvironment,inducing T cell apoptosis and escaping the immune surveillance to cause tumor immune escape.This article reviews the research progress of the relationship between the expression of PD-L and the prognosis of gynecologic malignancies.

Key words: Programmed death ligand-1, Programmed death protein 1, Gynecological malignancy, Prognosis

CLC Number:

R737.3

HAN Teng, TANG Liping. Advances in the relationship between the PD-L1 expression and the prognosis of gynecologic malignancies[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 468-470.

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Advances in the relationship between the PD-L1 expression and the prognosis of gynecologic malignancies

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