1 Castellsagué X,Alemany L,Quer M,et al.HPV involvement in head and neck cancers:comprehensive assessment of biomarkers in 3680 patients[J].J Natl Cancer Inst,2016,108(6):403. 2 Fung N,Faraji F,Kang H,et al.The role of human papillomavirus on the prognosis and treatment of oropharyngeal carcinoma[J].Cancer Metastasis Reviews,2017,36(3):449-461. 3 Ang KK,Harris J,Wheeler R,et al.Human papillomavirus and survival of patients with oropharyngeal cancer[J].N Engl J Med,2010,363(1):24-35. 4 Partlová S,Bouˇc ek J,Kloudová K,et al.Distinct patterns of intratumoral immune cell infiltrates in patients with HPV-associated compared to non-virally induced head and neck squamous cell carcinoma[J].Oncoimmunology,2015,4(1):e965570. 5 Wherry EJ,Ha SJ,Kaech SM,et al.Molecular signature of CD8+T cell exhaustion during chronic viral infection[J].Immunity,2007,27(4):670-684. 6 Seiwert TY,Burtness B,Mehra R,et al.Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck(KEYNOTE-012):an open-label,multicentre,phase 1b trial[J].Lancet Oncol,2016,17(7):956-965. 7 Seiwert TY,Zuo Z,Keck MK,et al.Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas[J].Clin Cancer Res,2015,21(3):632-641. 8 Nasri E,Wiesen LB,Knapik JA,et al.Eps8 expression is significantly lower in p16+ head and neck squamous cell carcinomas(HNSCCs)compared with p16-HNSCCs[J].Hum Pathol,2018,72:45-51. 9 Ferris RL,Blumenschein G Jr,Fayette J,et al.Nivolumab for recurrent squamous-cell carcinoma of the head and neck[J].N Engl J Med,2016,375(19):1856-1867. 10 Prigge ES,Arbyn M,von Knebel Doeberitz M,et al.Diagnostic accuracy of p16INK4a immunohistochemistry in oropharyngeal squamous cell carcinomas:a systematic review and meta-analysis[J].Int J Cancer,2017,140(5):1186-1198. 11 Cai L,Ye Y,Jiang Q,et al.Epstein-Barr virus-encoded microRNA BART1 induces tumour metastasis by regulating PTEN-dependent pathways in nasopharyngeal carcinoma[J].Nat Commun,2015,6:7353. 12 Kang H,Kiess A,Chung CH.Emerging biomarkers in head and neck cancer in the era of genomics[J].Nat Rev Clin Oncol,2015,12(1):11-26. 13 Chan JY,Wong ST.The role of plasma Epstein-Barr virus DNA in the management of recurrent nasopharyngeal carcinoma[J].Laryngoscope,2014,124(1):126-130. 14 Straathof KC,Bollard CM,Popat U,et al.Treatment of nasopharyngeal carcinoma with Epstein-Barr virus-specific T lymphocytes[J].Blood,2005,105(5):1898-1904. 15 Louis CU,Straathof K,Bollard CM,et al.Adoptive transfer of EBV-specific T cells results in sustained clinical responses in patients with locoregional nasopharyngeal carcinoma[J].J Immunother,2010,33(9):983-990. 16 Comoli P,Pedrazzoli P,Maccario R,et al.Cell therapy of stage IV nasopharyngeal carcinoma with autologous Epstein-Barr virus-targeted cytotoxic T lymphocytes[J].J Clin Oncol,2005,23(35):8942-8949. 17 Li YY,Chung GT,Lui VW,et al.Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations[J].Nat commun,2017,8:14121. 18 张锐,王智煜,文孝婷,等.肿瘤免疫抑制微环境对肿瘤免疫治疗作用的研究进展[J].实用肿瘤学杂志,2016,30(2):167-171. 19 Cristescu R,Mogg R,Ayers M,et al.Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy[J].Science,2018,362(6411):3593. 20 Solomon B,Young RJ,Rischin D.Head and neck squamous cell carcinoma:genomics and emerging biomarkers for immunomodulatory cancer treatments[J].Semin Cancer Biol,2018,52(2):228-240. 21 Ferris RL.Immunology and immunotherapy of head and neck cancer[J].J Clin Oncol,2015,33(29):3293-3304. 22 Srivastava RM,Lee SC,Andrade Filho PA,et al.Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients[J].Clin Cancer Res,2013,19(7):1858-1872. 23 Ohtani T,Yamada Y,Furuhashi A,et al.Activated cytotoxic T-lymphocyte immunotherapy is effective for advanced oral and maxillofacial cancers[J].Int J Oncol,2014,45(5):2051-2057. 24 李川,李燕,白鹰.细胞因子疗法在肿瘤治疗中的应用[J].国际肿瘤学杂志,2013,40(8):590-592. |