Journal of Practical Oncology ›› 2021, Vol. 35 ›› Issue (2): 188-192.doi: 10.11904/j.issn.1002-3070.2021.02.017

• Review • Previous Articles    

Research progress of threonine and tyrosine kinase in tumor

BI Jiaqing1, QIN Qian1, MA Huihan1, MA Meijie1, FENG Qinmei2   

  1. 1. Shanxi Medical University,Taiyuan 030001,China;
    2. Department of Obstetrics and Gynecology,The Affiliated People's Hospital of Shanxi Medical University
  • Received:2020-07-22 Revised:2020-10-10 Online:2021-04-28 Published:2021-04-27

Abstract: Threonine and tyrosine kinase(TTK)are the core components of the spindle assembly checkpoint.Many studies have found that TTK inhibitors can be used in the treatment of malignant tumors.The combination of chemotherapy and radiotherapy improves the treatment effect,and TTK can be used as an independent biomarker to indicate prognosis.This article reviews the research progress of TTK inhibitors and their combined use with radiotherapy and chemotherapy in tumor therapy and TTK in predicting tumor prognosis.

Key words: TTK;Tumor treatment;Tumor prognosis

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