UBQLN1在宫颈癌中的表达及其对预后的影响

doi:10.11904/j.issn.1002-3070.2021.06.004

Abstract

Abstract: Objective The aim of this study was to investigate the expression of ubiquilin 1(UBQLN1)in cervical cancer and its correlation with prognosis. Methods The immunohistochemical method was used to detect the expression of UBQLN1 in 117 cervical cancer tissues and 32 paired adjacent tissues,and analyze the relationship between UBQLN1 expression and clinicopathological features,recurrence and metastasis,and survival time. Results The positive rate of UBQLN1 expression in cervical cancer tissues was 88.89%(104/117),and the positive rate of UBQLN1 expression in paired adjacent tissues was 56.25%(18/32).Its expression was related to age and histological grade(P＜0.05).Kaplan-Meier survival analysis showed that higher expression of UBQN1 was related to the shorter overall survival(OS)and disease free survival(DFS)in patients with cervical cancer(P＜0.05). Conclusion The overexpression of UBQLN1 is related to the poor prognosis of cervical cancer.UBQLN1 may play an important role in the occurrence and development of cervical cancer.

Key words: UBQLN1, Cervical cancer, Immunohistochemistry, Prognosis

CLC Number:

R737.3

WANG Lina, WANG Le, JIN Hong, LI Qi, CHENG Haiyan. The expression of UBQLN1 in cervical cancer and its effect on prognosis[J]. Journal of Practical Oncology, 2021, 35(6): 506-510.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2021.06.004

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2021/V35/I6/506

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The expression of UBQLN1 in cervical cancer and its effect on prognosis

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