肿瘤浸润B细胞与免疫治疗

doi:10.11904/j.issn.1002-3070.2022.06.004

Abstract

Abstract: B cells are an critical component of the tumor microenvironment.However,the impact of B cells on tumor progression and treatment response is still controversial,reflecting the heterogeneity of tumor infiltrating B cells(TIL-Bs)subsets.In fact,these TIL-Bs are polarized in different directions with the immune microenvironment in which they are located to obtain different phenotypes and functions,and at the same time reversely shape the composition and type of the microenvironment,eventually leading to completely different clinical outcomes.This article summarizes the composition characteristics and formation mechanism of TIL-Bs.Further,combined with clinical trials and preclinical studies,we try to explain the influence of TIL-Bs heterogeneity on the effect of tumor immunotherapy.Elucidating the composition,generation,and nature of associated immune networks of B cell subsets in tumors are of great importance for a comprehensive understanding of B cell responses in tumors and for the design of more effective cancer immunotherapies.

Key words: Tumor infiltrating B cells, Immune microenvironment, Tumor immunotherapy

CLC Number:

R73.36⁺2

CAO Wenjie, WEI Yuan, KUANG Dongming. Tumor infiltrating B cells and immunotherapies[J]. Journal of Practical Oncology, 2022, 36(6): 507-512.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2022.06.004

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2022/V36/I6/507

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Tumor infiltrating B cells and immunotherapies

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