PRACTICAL ONCOLOGY JOURNAL ›› 2012, Vol. 26 ›› Issue (4): 369-372.doi: 10.3969/j.issn.1002-3070.2012.04.019

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Myeloid-derived suppressor cells:a new target of cancer immunotherapy

WU Lihua1,WANG Dongliang1,ZHANG Yanqiao1,2   

  1. 1.Department of Internal Medicine,The Third Affiliated Hospital of Harbin Medical University,Harbin 150081;
    2.The cancer Institute of Harbin Medical University,Harbin 150081
  • Received:2012-02-23 Online:2012-08-28 Published:2014-12-03

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Abstract: Myeloid-derived suppressor cells(MDSCs)are a heterogeneous population of myeloid derived cells Which were amplified in pathological status,which is characterized as negatively regulating the anti-tumor immune response with the result of promoting tumorigenesis and cancer development.It is a promising strategy to enhance the effect of cancer immunotherapy through blocking the immunosuppressive pathway of MDSCs.

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