Claudin家族蛋白在炎症性肠病及肠炎相关性结直肠癌中的研究进展

doi:10.11904/j.issn.1002-3070.2024.03.010

Abstract

Abstract: In recent years,the generation,maintenance and regulation of the intestinal mucosal barrier have become a research focus in the occurrence,development,treatment,and prognosis of inflammatory bowel disease(IBD)and colitis associated colorectal cancer(CAC).Tight junction(TJ)proteins are an important component of the intestinal mucosal barrier,which the Claudin family proteins have become a research hotspot.This review mainly introduces the changes of Claudin protein in IBD and CAC,as well as the latest research progress on its role in the occurrence,development and clinical treatment of IBD and CAC.

Key words: Claudin protein, Inflammatory bowel disease, Colorectal cancer associated with enteritis, Intestinal barrier, Tight junction protein

CLC Number:

R735.35

ZENG Ruizhi, LI Yongqiang. Research progress of Claudin family proteins in inflammatory bowel disease and colitis associated colorectal cancer[J]. Journal of Practical Oncology, 2024, 38(3): 207-212.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2024.03.010

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2024/V38/I3/207

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Research progress of Claudin family proteins in inflammatory bowel disease and colitis associated colorectal cancer

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