非编码RNA调控铁死亡介导肝细胞癌索拉非尼耐药的研究进展

doi:10.11904/j.issn.1002-3070.2025.03.012

Abstract

Abstract: Ferroptosis is a non-apoptotic programmed cell death driven by iron ion-mediated lipid peroxidation,which is closely related to the occurrence and development of various tumors.In recent years,many studies have shown that non-coding RNA(ncRNA)can affect tumor drug resistance by regulating the ferroptosis pathway.This article summarizes the molecular mechanisms of ncRNAs regulating sorafenib resistance in hepatocellular carcinoma(HCC)through ferroptosis,with a focus on the regulatory roles of different ncRNA subtypes such as microRNA(miRNA),long noncoding RNA(lncRNA),and circular RNA(circRNA).The article not only contributes to a deeper analysis of the key molecular mechanisms by which ncRNA mediate sorafenib resistance in HCC through ferroptosis pathways,but also provides a theoretical basis for exploring novel diagnostic biomarkers and therapeutic targets for HCC in the future.

Key words: Hepatocellular carcinoma, Non-coding RNA, Ferroptosis, Sorafenib, Biomarkers

CLC Number:

R735.7

ZHU Lei, HAO Dandan. Research progress on non-coding RNAs in the regulation of ferroptosis mediated sorafenib resistance in hepatocellular carcinoma[J]. Journal of Practical Oncology, 2025, 39(3): 256-261.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2025.03.012

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2025/V39/I3/256

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Research progress on non-coding RNAs in the regulation of ferroptosis mediated sorafenib resistance in hepatocellular carcinoma

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