Abstract: The constructing experimental mouse models that conform to the biological characteristics of human liver cancer are crucial for understanding the pathogenesis of liver cancer and testing new therapeutic drugs.At present,the commonly used laboratory mouse models for liver cancer are mainly divided into three types based on their construction methods:chemically/diet-induced mouse models,genetically engineered mouse models,and transplanted mouse models.However,these three types of liver cancer mice also differ in their construction methods,scope of application,and characteristics of liver cancer tissue types.This review describes the differences in construction methods,tumor formation time,and applicability among different liver cancer mouse models,aiming to provide a reference for researchers in selecting suitable mouse models.

Key words: Hepatocellular carcinoma, Mouse, Animal model