lncRNA在肝细胞癌索拉非尼耐药中的最新研究进展

doi:10.11904/j.issn.1002-3070.2021.06.015

Abstract

Abstract: Hepatocellular carcinoma(HCC)is one of the most common and deadly cancers in the world.Many patients with advanced stage are mainly treated with drugs.Sorafenib,as a unique targeted drug for advanced HCC,has been widely used in clinical practice.However,sorafenib targeted therapy is not only a single drug therapy with low efficiency,but also drug resistance is a big problem that needs to be solved urgently.Recent studies have shown that long non-coding RNA(lncRNA)is closely related to the occurrence,development,invasion and metastasis,prognosis and drug resistance of HCC,and it has become an emerging hot spot in the drug resistance research.This article reviews the latest findings of lncRNAs in the sorafenib resistance of HCC and specific mechanisms of regulating resistance.

Key words: Hepatocellular carcinoma, Long non-coding RNA, Sorafenib, Drug resistance

CLC Number:

R735.7

JI Lei, JI Daolin, BAO Dongdong, TAN Gang. The latest research progress of long non-coding RNA in sorafenib resistance of hepatocellular carcinoma[J]. Journal of Practical Oncology, 2021, 35(6): 562-567.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2021.06.015

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2021/V35/I6/562

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The latest research progress of long non-coding RNA in sorafenib resistance of hepatocellular carcinoma

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