NK细胞极化在子宫内膜癌中的作用

doi:10.11904/j.issn.1002-3070.2021.06.009

Abstract

Abstract: Natural killer(NK)cells are a type of cytotoxic innate immune cells and are considered as cells of the main effector, but the function of NK cells has undergone tremendous changes in the process of tumor progression.Endometrial cancer(EC)is one of the most common tumors in the female reproductive system, and the immune escape mechanism is at the basis for the progress of EC.Recent studies have found that the microenvironment of EC can not only reduce the recruitment of cytotoxic NK cells to the tumor site, but also change its phenotype and reduce its killing function.Moreover, NK cells with cytotoxicity in the tumor microenvironment gradually shift to an immune tolerance phenotype, which promotes tumor growth and tumor angiogenesis.How to prevent the polarized microenvironment from damaging the toxicity of NK cells and inhibiting the NK cells that promote tumor growth has become the focus of our attention.

Key words: Natural killer cells, Endometrial cancer, Tumor microenvironment

CLC Number:

R737

MU Guannan, MA Qiang. The role of NK cell polarization in endometrial cancer[J]. Journal of Practical Oncology, 2021, 35(6): 534-537.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2021.06.009

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2021/V35/I6/534

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The role of NK cell polarization in endometrial cancer

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