ILC2s在肿瘤免疫调控中的研究进展

doi:10.11904/j.issn.1002-3070.2022.06.014

Abstract

Abstract: Type 2 innate lymphoid cells(ILC2s)are a kind of unique immune effectors’ cells,which play an important role in anti-infection,regulating inflammation and maintaining immune homeostasis.Recent studies have shown that ILC2s are also involved in the regulation of tumor immunity,and ILC2s have been found in the tumor microenvironment.However,the role of ILC2s in tumor immune response and immunotherapy has not been clarified.Studies have shown that ILC2s expression immune checkpoints,interleukin-33(IL-33)can activate ILC2s in the tumor microenvironment,and the inhibitory checkpoint receptor PD-1 of ILC2s expression,PD-1 blockers directly act on ILC2s,reduce the inherent PD-1 inhibition of ILC2s cells,finally increase the infiltration of CD8⁺ cytotoxic T lymphocytes(CTL)in tumor tissues,and enhances the tumor immune response.The activated tumor ILC2s can be used as the target of anti-PD-1 immunotherapy.This review will discuss the possible mechanisms of ILC2s involved in the regulation of tumor immunity and explore new targets of tumor immune checkpoint inhibitors.

Key words: Type 2 innate lymphoid cells, Tumor microenvironment, Tumor immunity

CLC Number:

ZHANG Shumin, ZHANG Gong. Research progress of ILC2s in tumor immune regulation[J]. Journal of Practical Oncology, 2022, 36(6): 566-569.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2022.06.014

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Research progress of ILC2s in tumor immune regulation

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