乳酸化修饰:癌症治疗中的新兴靶点

doi:10.11904/j.issn.1002-3070.2025.05.011

Abstract

Abstract: Post-translational modification of protein is a key mechanism for regulating cancer development and immune responses,and has become an important target for cancer diagnosis and treatment.Among them,lactylation modification provides a new perspective for the precise prevention and control of tumors by affecting metabolism and epigenetics.Lactylation modification precisely regulates the functions of histone and non-histone,affecting tumor cell characteristics,microenvironment acidification,and immune cell functions,becoming a key hub connecting metabolic reprogramming and malignant phenotypes.This article reviews the regulatory roles of lactylation modification in tumor development,immune escape,clinical translation,and explores the potential of targeted inhibition of lactylation modification and its related pathways,as well as the inhibition of key enzyme activity.

Key words: post-translational modification, lactylation, cancer, tumor microenvironment

CLC Number:

R730.2

XIN Xin, XIONG Wenjing, ZHANG Chunnuan, LI Xiaojing, GAO Xue, ZHANG Yue. Lactylation modification:an emerging target in cancer therapy[J]. Journal of Practical Oncology, 2025, 39(5): 433-436.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2025.05.011

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2025/V39/I5/433

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Lactylation modification:an emerging target in cancer therapy

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