Journal of Practical Oncology ›› 2025, Vol. 39 ›› Issue (5): 428-432.doi: 10.11904/j.issn.1002-3070.2025.05.010

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Research progress of phytochemicals in tumor immunotherapy

ZHANG Xuan1, LI Juan2, FANG Chuanfeng1, TIAN Hong1, LIU Jiaren1,3   

  1. 1. Department of Laboratory Diagnosis,The Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China;
    2. Department of Laboratory Medicine,Fuwai Cardiovascular Disease Hospital,Yunnan Province;
    3. Heilongjiang Molecular Medicine Engineering Technology Research Center
  • Received:2025-02-12 Revised:2025-06-04 Online:2025-10-28 Published:2025-11-07

Abstract: In recent years,the incidence and mortality of malignant tumors have been increasing year by year,becoming a serious challenge to global public health.Unlike traditional treatment methods,tumor immunotherapy activates the body's own immune system to against tumors,and has significant advantage such as minimal side effects,long-lasting efficacy,and strong targeting.However,immunotherapy also has issues such as frequent adverse reactions and high treatment costs.In order to enhance the efficacy of immunotherapy,some phytochemicals are used in the field of immunotherapy as modulators.These phytochemicals not only increase the sensitivity of tumor cells to immune cells,but also reduce the expression of immune checkpoint proteins.Therefore,this article provides a review of phytochemicals that play an important role in tumor immunotherapy and their related mechanisms of action.

Key words: phytochemicals, tumor, immunotherapy

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