Abstract: Objective To compare the effect and safety between microdose heparin and low-dose heparin in the treatment of surgical patients with solid tumors complicated with disseminated intravascular coagulation.Methods Fifty-eight cases with DIC were randomly divided into two group:30 cases treated with microdosage heparin(group MMDH),28 cases treated with low-dose heparin(group MLDH).The miscoheparin group were pumped with heparin(10~25mg/d)continuously for 3 to 5 days,and the low-dose heparin group were punmped with heparin(50~100mg/d)continuously for 3 to 5 days too.Other therapeutic principle was the same in the two groups,PT、APTT、PLT、Fbg、D-D were observed in the two groups before the treatment and after the treatment;cure rate、bleeding、the length of stay in ICU、the length of time of applying ventilator and the 28-day case fatality were recorded.Results In two groups,there were no significant differences in PT and APTT between pretreatment and post-teatment(P＞0.05).There were significant difference in other laboratory parameters(P＜0.05);Cure rate of miscoheparin group and low-dose heparin were 46.7% and 21.4%,respectively.There was significantly different between the two groups(P＜0.05);After pumping into heparin,1 case severely hemoyyhaged in the miscoheparin,while the low-dose group were 7 cases.There was significantly different between the two groups(P＜0.05);The length of stay in ICU and the length of time of applying ventilator in the miscooheparin were shorter than those in the low-heparin(P＜0.01),but there was no significant difference in the 28-day case-fatality between the two groups(P＞0.05).Conclusion Using miscoheparin continuous transfusion remedied surgical patients with solid tumors complicated with disseminated intravascular coagulation and could increase cure rate and effect,and reduce bleeding and especially apply to the elderly patients and intracerbral hemorrhage.