Abstract: Objective To evaluate the efficacy and safety of intervenous drop infusion of Kanglaite injection and intraperitoneal catheter drainage combined with hydroxycamptothecin and bruceolic oil emulsion in advanced tumor patients with malignant ascites.Methods 65 advanced tumor patients with malignant ascites were chosen and divided randomly into two groups:treatment group and control group.37 patients of treatment group were given hydroxycamptothecin 20 mg,bruceolic oil emulsion 60 ml by intraperitoneal injection with a repetition every week,4 times altogether.Simultaneously,an intervenous drop infusion of Kanglaite injection 200 ml was given every day,21 day altogether.And 28 patients of control group were given DDP 80-100mg by intraperitoneal injection with a repetition every week,4 times altogether.The effects were evaluated after a month.Results The malignant ascites reduced:the treatment group efficient 78.38%(29/37),and the control group efficient 50%(14/28).The toxic reactions and adverse reactions of treatment group were less than that of control group.The patients of treatment group received a better quality of life.Conclusion Intraperitoneal catheter combined with hydroxycamptothecin,bruceolic oil emulsion and intervenous drop infusion of Kanglaite injection is feasible and effective for advanced tumor patients with malignant ascites.