CDC5L基因与恶性肿瘤的研究进展

doi:10.11904/j.issn.1002-3070.2025.04.016

Abstract

Abstract: Cell division cycle 5 like(CDC5L)is a nuclear protein encoded by the CDC5L gene,which exhibits cell cycle-dependent expression and plays a critical role throughout the cell cycle process.The expression and degradation of CDC5L in the cell cycle process are strictly regulated.Its expression disorder can cause the cell cycle to run out of control,interfere with the mitosis of cells,and then cause the instability of cell chromosomes,which ultimately promotes the occurrence of tumors.This review focuses on the structure and function of CDC5L,summarizing the mechanisms of the CDC5L gene in tumorigenesis and its relationship with prognosis.

Key words: Cell division cycle 5 like, Cell cycle, Tumor, Malignant phenotype

CLC Number:

R730.7

LIANG Xiaodan, GUO Haonan. Research advances on the CDC5L gene in malignant tumors[J]. Journal of Practical Oncology, 2025, 39(4): 358-362.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2025.04.016

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2025/V39/I4/358

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Research advances on the CDC5L gene in malignant tumors

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