Abstract: Objective The aim of this study was to analyze the gastroscopic screening results of high-risk populations for gastric cancer in Gejiu City from 2021 to 2023,and to provide theoretical basis for gastric cancer prevention and treatment in this city. Methods A questionnaire survey was conducted to assess the risk of gastric cancer among residents aged 40 and above in Gejiu City.Gastroscopy and pathological biopsy were performed on those assessed as high-risk for gastric cancer,and the screening results were statistically analyzed. Results From 2021 to 2023,a total of 24,391 residents were evaluated,of which 7,978 were at high-risk of gastric cancer.Among them,2,473 individuals completed gastroscopy and pathological examination,with a screening rate of 31.00%.Twenty-eight cases of gastric cancer were detected,and the detection rate of gastric cancer in high-risk populations was 1.13%;Among them,there were 9 cases of early-stage gastric cancer,with an early diagnosis rate of 46.43%.The overall infection rate of Helicobacter pylori(HP)was 62.00%,and it increased significantly with the severity of gastric mucosal lesions(P＜0.001).The detection rates of gastric cancer and precancerous lesions were significantly higher in males,ethnic minorities,and HP-infected individuals was higher than those in females,Han people,and non-HP-infected individuals,and the differences were statistically significant(P＜0.05).Following-up results showed that 1 case(2.08%)of severe atrophic gastritis progressed to early gastric cancer,and 2 cases(6.67%)of low-grade intraepithelial neoplasia progressed to early gastric cancer. Conclusion The detection rate of gastric cancer among high-risk populations in Gejiu City was relatively high,however the proportion of early-stage cases remained low,indicating that the rate of early diagnosis still needs to be improved.Males,ethnic minorities,and HP-infected individuals are key target groups for gastric cancer prevention and control in this region.HP infection may be closely related to the progression of gastric mucosal lesions and the occurrence of gastric cancer,and relevant interventions should be strengthened.

Key words: gastric cancer, high-risk population, gastroscopic screening, helicobacter pylori, Gejiu City