Abstract: Objective The aims of this study were to screening of high-risk population of breast cancer in Urumqi,to discuss the participation rate of the screening,the detection rate of breast disease by ultrasound and X-ray photography,and the early diagnosis rate of breast cancer. Methods Among female residents of Urumqi between 40 and 74 years old,the high-risk population of breast cancer was assessed through the questionnaire of anti-cancer risk assessment.After informed consent,the 40 to 44 years old women were examined by ultrasound,and the results of BI-RADS level 3 or higher results were further examined by X-ray examination.Ultrasound combined with X-ray examination were used to women over 45 years of age.The BI-RADS level 3 was regarded as suspicious positive,BI-RADS level 4 and above were regarded as positive.All test results were further analyzed. Results A total of 27,704 at high risk of breast cancer were assessed by questionnaire survey,and 11,752 people actually completed the screening with a participation rate of 42.4%.Among them,the 50~59 years old age group had the highest participation rate(46.3%),and the difference between different age groups was statistically significant(P＜0.001).The detection rate of ultrasound examination was 27.1%,the detection rate of X-ray mammography was 61.3%,and the detection rate of combined examination was 68.4%.The difference of detection rate was statistically significant with different examination techniques(P＜0.001).The detection rate of X-ray mammography in all ages was higher than that of ultrasound examination.The combined examination had the highest detection rate,there was significant difference in the detection rate of different examination techniques in different age groups(P＜0.001).Compared with the three techniques,the suspicious positive and positive detection rates of combined ultrasound and X-ray mammography were higher in different age groups,and the difference in positive lesion detection rates of different examination techniques in different age groups was statistically significant(P＜0.001).Among the positive lesions,39 people were followed up for pathological examination,and were diagnosed as breast cancer.The detection rate was 0.33%(332/100,000),and the rate of early diagnosis was 79.5%. Conclusion Based on high risk assessment and assessing high-risk groups,the ultrasound combined with and X-ray examination can improve the detection rate of early breast cancer.

Key words: Screening, Breast cancer, Ultrasonography, X-ray, Detection rate