Abstract: Objective The aim of this study was to analyze the screening results of colorectal cancer among urban residents in Ningbo City from 2019 to 2023,and provide reference for optimizing colorectal cancer screening strategies. Methods From 2019 to 2023,permanent residents aged 45 to 74 in Haishu district,Jiangbei district,Yinzhou district,Beilun district,Zhenhai district,and Fenghua district of Ningbo City were selected as screening subjects.They filled out a cancer risk assessment questionnaire and underwent fecal occult blood testing.Risk assessment was conducted according to the unified standards formulated by the National Urban Cancer Early Diagnosis and Treatment Project Group.High risk subjects underwent colonoscopy examination,and the high-risk rate,colonoscopy compliance rate,and lesion detection rate of colorectal cancer were analyzed. Results From 2019 to 2023,a total of 60,268 individuals were assessed for colorectal cancer risk,with 18,607 identified as high-risk,resulting in a high-risk rate of 30.87%.The high-risk rate for males(54.91%)was higher than that for females(16.24%)(P＜0.05).A total of 4,370 people completed colonoscopy examination,with a compliance rate of 23.49%.The compliance rate of females(24.60%)was higher than that of males(22.95%)(P＜0.05).14 cases of colorectal cancer,161 cases of precancerous lesions,and 695 cases of other benign lesions were detected,with detection rates of 0.32%,3.68%,and 15.90%,respectively.The detection rate of precancerous lesions in males(4.24%)was higher than that in females(2.61%)(P＜0.05).As age increased,the high-risk rate of colorectal cancer,the detection rate of colorectal cancer,the detection rate of precancerous lesions,and the detection rate of other benign lesions showed an upward trend,while the compliance rate of colonoscopy showed a downward trend(P＜0.05). Conclusion Establishing a secondary screening mechanism of "risk assessment-colonoscopy" with a focus on males and the elderly populations,combined with mobile education platforms and green channels for diagnosis and treatment,can improve the screening effectiveness of colorectal cancer.

Key words: Colorectal cancer, Risk assessment, Screening, Early diagnosis and treatment of cancer