m6A修饰阅读蛋白YTH在结直肠癌中的机制研究进展

doi:10.11904/j.issn.1002-3070.2023.02.014

Abstract

Abstract: N6-methyladenosine(m6A)is the most abundant internal chemical modifications in eukaryotic mRNA and long non-coding RNAs(lncRNAs),and its process is controlled by methyltransferase,demethylase and reader proteins are involved in the completion and rely on the three dynamic regulation.Among them,the YT521-B homology domain(YTH)protein is a kind of mature m6A reading protein,which can specifically recognize m6A-containing RNA and mediate its function,and is related to the occurrence and development of various tumors.However,little is known about the role of YTH proteins in colorectal cancer.This article reviews the structure,function and related pathway mechanism of the YTH protein in colorectal cancer,so as to provide the reference for the personalized treatment for colorectal cancer.

Key words: YT521-B homology domain protein, M6A readers protein, Colorectal cancer

CLC Number:

R735

CHEN Liming, XIA Min. Research progress in the mechanism of m6A-modified reading protein YTH in colorectal cancer[J]. Journal of Practical Oncology, 2023, 37(2): 170-174.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2023.02.014

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2023/V37/I2/170

References

1 Boccaletto P,Stefaniak F,Ray A,et al.MODOMICS:a database of RNA modification pathways.2021 update[J].Nucleic Acids Res,2022,50(1):231-235.
2 Zhang H,Shi X,Huang T,et al.Dynamic landscape and evolution of m6A methylation in human[J].Nucleic Acids Res,2020,48(11):6251-6264.
3 Meyer KD,Jaffrey SR.Rethinking m6A readers,writers,and erasers[J].Annu Rev Cell Dev Biol,2017,33(1):319-342.
4 Shi R,Ying S,Li Y,et al.Linking the YTH domain to cancer:the importance of YTH family proteins in epigenetics[J].Cell Death Dis,2021,12(4):346.
5 Xu C,Wang X,Liu K,et al.Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain[J].Nat Chem Biol,2014,10(11):927-929.
6 Patil DP,Pickering BF,Jaffrey SR.Reading m6A in the transcriptome:m6A-binding proteins[J].Trends Cell Biol,2018,28(2):113-127.
7 Wang X,Zhao BS,Roundtree IA,et al.N6-methyladenosine modulates messenger RNA translation efficiency[J].Cell,2015,161(6):1388-1399.
8 Nguyen Ba AN,Yeh BJ,van Dyk D,et al.Proteome-wide discovery of evolutionary conserved sequences in disordered regions[J].Sci Signal,2012,5(215):1.
9 Zaccara S,Jaffrey SR.A unified model for the function of YTHDF proteins in regulating m6A-modified mRNA[J].Cell,2020,181(7):1582-1595.
10 Li Y,Bedi RK,Moroz-Omori EV,et al.Structural and dynamic insights into redundant function of YTHDF proteins[J].J Chem Inf Model,2020,60(12):5932-5935.
11 Berlivet S,Scutenaire J,Deragon JM,et al.Readers of the m6A epitranscriptomic code[J].Biochim Biophys Acta Gene Regul Mech,2019,1862(3):329-342.
12 Li A,Chen YS,Ping XL,et al.Cytoplasmic m6A reader YTHDF3 promotes mRNA translation[J].Cell Res,2017,27(3):444-447.
13 Liu J,Dou X,Chen C,et al.N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription[J].Science,2020,367(6477):580-586.
14 Roundtree IA,Luo GZ,Zhang Z,et al.YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs[J].Elife,2017,6:e31311.
15 Kretschmer J,Rao H,Hackert P,et al.The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5′-3′exoribonuclease XRN1[J].RNA,2018,24(10):1339-1350.
16 Nishizawa Y,Konno M,Asai A,et al.Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer[J].Oncotarget,2018,9(7):7476-7486.
17 Bai Y,Yang C,Wu R,et al.YTHDF1 regulates tumorigenicity and cancer stem cell-like activity in human colorectal carcinoma[J].Front Oncol,2019,9:332.
18 Han B,Yan S,Wei S,et al.YTHDF1-mediated translation amplifies Wnt-driven intestinal stemness[J].EMBO Rep,2020,21(4):e49229.
19 Wang S,Yuan B,Wang Y,et al.Clinicopathological and prognostic significance of PD-L1 expression in colorectal cancer:a meta-analysis[J].Int J Colorectal Dis,2021,36(1):117-130.
20 Liu YZ,Han DT,Shi DR,et al.Pathological significance of abnormal recepteur d′origine nantais and programmed death ligand 1 expression in colorectal cancer[J].World J Gastrointest Oncol,2020,12(11):1216-1236.
21 Gao Y,Nihira NT,Bu X,et al.Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy[J].Nat Cell Biol,2020,22(9):1064-1075.
22 余诗俊,栗丽,窦宁,等.m6A甲基化修饰调控结直肠癌细胞中PD-L1表达[J].兰州大学学报(医学版),2021,47(1):47-51.
23 Liu X,Liu L,Dong Z,et al.Expression patterns and prognostic value of m(6)A-related genes in colorectal cancer[J].Am J Transl Res,2019,11(7):3972-3991.
24 Ni W,Yao S,Zhou Y,et al.Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3[J].Mol Cancer,2019,18(1):143.
25 Chen RX,Chen X,Xia LP,et al.N(6)-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis[J].Nat Commun,2019,10(1):4695.
26 Wu J,Wang Y,Xu X,et al.Transcriptional activation of FN1 and IL11 by HMGA2 promotes the malignant behavior of colorectal cancer[J].Carcinogenesis,2016,37(5):511-521.
27 Tanabe A,Tanikawa K,Tsunetomi M,et al.RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated[J].Cancer Lett,2016,376(1):34-42.
28 Nagaraju GP,Bramhachari PV,Raghu G,et al.Hypoxia inducible factor-1α:Its role in colorectal carcinogenesis and metastasis[J].Cancer Lett,2015,366(1):11-18.

[1]	ZHU Xiaoyun, GAO Xia, WANG Qian, SHU Qi. Analyses of colorectal cancer screening results among community residents in Jinshan district,Shanghai,2013—2021 [J]. Journal of Practical Oncology, 2023, 37(2): 112-116.
[2]	WANG Bingping, DUAN Jinkai, ZHANG Shuang, GAO Yanwei, REN Meng, CHEN Liangquan, GAO Weishi. Research on NK cells combined with PD-1 monoclonal antibody to kill colorectal cancer cells [J]. Journal of Practical Oncology, 2023, 37(2): 130-136.
[3]	ZHOU Junfeng, ZENG Zhiyao, LUO Yongfu, HE Chao. Effects of miR-765 targeting ARID1A on the invasion and migration of colorectal cancer cells [J]. Journal of Practical Oncology, 2023, 37(1): 32-38.
[4]	LI Bo, PENG Xiaolin, WANG Shanshan, LI Gairui, ZHAO Dan, PENG Ji. Comparative study on application effect of two risk assessment models in screening colorectal cancer [J]. Journal of Practical Oncology, 2022, 36(3): 197-202.
[5]	CHEN Su, SUI Hong. Research progress of anti-HER2 therapy in metastatic colorectal cancer [J]. Journal of Practical Oncology, 2022, 36(3): 288-292.
[6]	CHEN Han, LUO Xiaoyong, LI Chaoping, GUO Cairu, JU Wencui, ZHAI Yangyang, SHI Xinpeng. The effect of lncRNA CASC2 on the function and angiogenesis of colorectal cancer cells [J]. Journal of Practical Oncology, 2022, 36(2): 111-118.
[7]	ZHAO Xuan, LI Guodong, LIU Ming. Research progress of metallothionein in colorectal cancer [J]. Journal of Practical Oncology, 2021, 35(6): 538-541.
[8]	WANG Langyue, ZHAO Qi, WU Huaxing. New progress in the regulation of colorectal cancer by metabolites derived from gut microbiota [J]. Journal of Practical Oncology, 2021, 35(6): 547-551.
[9]	HAN Shuling, YAO Yang, LIU Chao, ZHANG Yanqiao. Research status of intestinal microbes affecting the efficacy of chemotherapy for colorectal cancer [J]. Journal of Practical Oncology, 2021, 35(5): 476-479.
[10]	HUANG Rui, LIU Chao, ZHANG Yanqiao. A systematic review of simvastatin in the treatment of colorectal cancer [J]. Journal of Practical Oncology, 2021, 35(4): 365-369.
[11]	LIU Wen, QIAO Wenbo. Clinical research status of programmed cell death protein-1 and its ligand in colorectal cancer [J]. Journal of Practical Oncology, 2021, 35(4): 370-375.
[12]	ZHU Gongjian, ZHU Yitong, DING Gaoheng, WANG Hongzong, DU Meixia, LIU Yuqin. Analysis for characteristics and trends of colorectal cancer in Gansu cancer registry areas,2009—2015 [J]. Journal of Practical Oncology, 2021, 35(3): 212-217.
[13]	GUO Piaoting, MIN Li, CHEN Jianjun, WANG Xin, NI Siyi. Salvianolic acid B regulates ROS to inhibit the proliferation and promote apoptosis in colorectal cancer HCT-116 cells [J]. Journal of Practical Oncology, 2020, 34(6): 504-510.
[14]	GUO Piaoting, ZOU Yang. LncRNA SOX2OT sponge adsorbs miR-34a to promote SOX2 expression and enhance multidrug resistance in colorectal cancer [J]. Journal of Practical Oncology, 2020, 34(5): 398-403.
[15]	DONG Manku, JIANG Fuquan, LIN Haiguan, SUN Xiaomin, LIU Jingxin, HU Gang, YANG Jianwu. LncRNA BLACAT1 targeting LEMD1 promotes the proliferation and metastasis of colorectal cancer cells [J]. Journal of Practical Oncology, 2020, 34(5): 418-424.

Research progress in the mechanism of m6A-modified reading protein YTH in colorectal cancer

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments