肠道微生物群衍生的代谢产物调控结直肠癌的新进展

doi:10.11904/j.issn.1002-3070.2021.06.012

Abstract

Abstract: Changes in the intestinal ecosystem will affect human health and even cause colorectal cancer.A large amount of evidence shows that a pathological imbalance of the microbiota is common in the intestines of patients with colorectal cancer,and metabolites derived from imbalanced microbiota can also affect the occurrence and development of colorectal cancer.This article reviews the ways which metabolites of specific gut microbiota trigger the progression of colorectal cancer,summarizes the latest progress in the contribution of metabolites from gut microbiota to colorectal cancer,and considers the accumulative effect of metabolites and the combination of multiple metabolites to predict and prevent colorectal cancer.

Key words: Intestinal microbiota, Colorectal cancer, Metabolites

CLC Number:

R735.3

WANG Langyue, ZHAO Qi, WU Huaxing. New progress in the regulation of colorectal cancer by metabolites derived from gut microbiota[J]. Journal of Practical Oncology, 2021, 35(6): 547-551.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2021.06.012

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2021/V35/I6/547

References

1 Wong SH,Yu J.Gut microbiota in colorectal cancer:mechanisms of action and clinical applications[J].Nat Rev Gastroenterol Hepatol,2019,16(11):690-704.
2 Louis P,Hold GL,Flint HJ.The gut microbiota,bacterial metabolites and colorectal cancer[J].Nat Rev Microbiol,2014,12(10):661-672.
3 Postler TS,Ghosh S.Understanding the holobiont:how microbial metabolites affect human health and shape the immune system[J].Cell Metab,2017,26(1):110-130.
4 Hu J,Lin S,Zheng B,et al.Short-chain fatty acids in control of energy metabolism[J].Crit Rev Food Sci Nutr,2018,58(8):1243-1249.
5 Stockinger B,Di Meglio P,Gialitakis M,et al.The aryl hydrocarbon receptor:multitasking in the immune system[J].Annu Rev Immunol,2014,32:403-432.
6 Rothhammer V,Mascanfroni ID,Bunse L,et al.Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor[J].Nat Med,2016,22(6):586-597.
7 Jin UH,Cheng Y,Park H,et al.Short chain fatty acids enhance aryl hydrocarbon(Ah)responsiveness in mouse colonocytes and Caco-2 human colon cancer cells[J].Sci Rep,2017,7(1):10163.
8 Michael AJ.Biosynthesis of polyamines and polyamine-containing molecules[J].Biochem J,2016,473(15):2315-2329.
9 Duboc H,Rajca S,Rainteau D,et al.Connecting dysbiosis,bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases[J].Gut,2013,62(4):531-539.
10 Proietti M,Perruzza L,Scribano D,et al.ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens[J].Nat Commun,2019,10(1):250.
11 Barrett M,Hand CK,Shanahan F,et al.Mutagenesis by Microbe:the role of the microbiota in shaping the cancer genome[J].Trends Cancer,2020,6(4):277-287.
12 Habermeyer M,Roth A,Guth S,et al.Nitrate and nitrite in the diet:how to assess their benefit and risk for human health[J].Mol Nutr Food Res,2015,59(1):106-128.
13 Garaycoechea JI,Crossan GP,Langevin F,et al.Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells[J].Nature,2018,553(7687):171-177.
14 Allen J,Sears CL.Impact of the gut microbiome on the genome and epigenome of colon epithelial cells:contributions to colorectal cancer development[J].Genome Med,2019,11(1):11.
15 Si H,Yang Q,Hu H,et al.Colorectal cancer occurrence and treatment based on changes in intestinal flora[J].Semin Cancer Biol,2020[Online ahead of print].
16 Wilson MR,Jiang Y,Villalta PW,et al.The human gut bacterial genotoxin colibactin alkylates DNA[J].Science,2019,363(6428):7785.
17 Zheng D,Liwinski T,Elinav E.Interaction between microbiota and immunity in health and disease[J].Cell Res,2020,30(6):492-506.
18 Yu YN,Fang JY.Gut microbiota and colorectal cancer[J].Gastrointest Tumors,2015,2(1):26-32.
19 Song X,Gao H,Lin Y,et al.Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis[J].Immunity,2014,40(1):140-152.
20 Song X,Sun X,Oh SF,et al.Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis[J].Nature,2020,577(7790):410-415.
21 Geuking MB,Burkhard R.Microbial modulation of intestinal T helper cell responses and implications for disease and therapy[J].Mucosal Immunol,2020,13(6):855-866.
22 Pandolfi JB,Ferraro AA,Sananez I,et al.ATP-Induced inflammation drives tissue-resident Th17 cells in metabolically unhealthy obesity[J].J Immunol,2016,196(8):3287-3296.
23 Kroemer G,Zitvogel L.Inosine:novel microbiota-derived immunostimulatory metabolite[J].Cell Res,2020,30(11):942-943.
24 Mager LF,Burkhard R,Pett N,et al.Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy[J].Science,2020,369(6510):1481-1489.
25 Vancamelbeke M,Vermeire S.The intestinal barrier:a fundamental role in health and disease[J].Expert Rev Gastroenterol Hepatol,2017,11(9):821-834.
26 Windey K,De Preter V,Verbeke K.Relevance of protein fermentation to gut health[J].Mol Nutr Food Res,2012,56(1):184-196.
27 Nguyen LH,Ma W,Wang DD,et al.Association between sulfur-metabolizing bacterial communities in stool and risk of distal colorectal cancer in men[J].Gastroenterology,2020,158(5):1313-1325.
28 Wang Q,Xu R.Data-driven multiple-level analysis of gut-microbiome-immune-joint interactions in rheumatoid arthritis[J].BMC Genomics,2019,20(1):124.
29 Wlodarska M,Luo C,Kolde R,et al.Indoleacrylic acid produced by commensal peptostreptococcus species suppresses inflammation[J].Cell Host Microbe,2017,22(1):25-37.
30 马志刚,朱晓麟,马丽红,等.基于多靶点粪便FIT-DNA联合检测技术的结直肠癌早期筛查结果分析[J].中华结直肠疾病电子杂志,2019,8(6):616-621.
31 Zhu W,Miyata N,Winter MG,et al.Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer[J].J Exp Med,2019,216(10):2378-2393.
32 Uchiyama K,Sakiyama T,Hasebe T,et al.Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development[J].Sci Rep,2016,6:32094.
33 Guo M,Li Z.Polysaccharides isolated from Nostoc commune Vaucher inhibit colitis-associated colon tumorigenesis in mice and modulate gut microbiota[J].Food Funct,2019,10(10):6873-6881.
34 Pujo J,Petitfils C,Le Faouder P,et al.Bacteria-derived long chain fatty acid exhibits anti-inflammatory properties in colitis[J].Gut,2020[Online ahead of print].
35 Blandford LE,Johnston EL,Sanderson JD,et al.Promoter orientation of the immunomodulatory Bacteroides fragilis capsular polysaccharide A(PSA)is off in individuals with inflammatory bowel disease(IBD)[J].Gut Microbes,2019,10(5):569-577.
36 Im E,Martinez JD.Ursodeoxycholic acid(UDCA)can inhibit deoxycholic acid(DCA)-induced apoptosis via modulation of EGFR/Raf-1/ERK signaling in human colon cancer cells[J].J Nutr,2004,134(2):483-486.
37 Liu L,Dong W,Wang S,et al.Deoxycholic acid disrupts the intestinal mucosal barrier and promotes intestinal tumorigenesis[J].Food Funct,2018,9(11):5588-5597.
38 Lee DG,Hori S,Kohmoto O,et al.Ingestion of difructose anhydride III partially suppresses the deconjugation and 7α-dehydroxylation of bile acids in rats fed with a cholic acid-supplemented diet[J].Biosci Biotechnol Biochem,2019,83(7):1329-1335.
39 Mizutani S,Yamada T,Yachida S.Significance of the gut microbiome in multistep colorectal carcinogenesis[J].Cancer Sci,2020,111(3):766-773.
40 Hebels DG,Sveje KM,de Kok MC,et al.N-nitroso compound exposure-associated transcriptomic profiles are indicative of an increased risk for colorectal cancer[J].Cancer Lett,2011,309(1):1-10.
41 Guo H,Chou WC,Lai Y,et al.Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites[J].Science,2020,370(6516):9097.
42 Barrasa JI,Olmo N,Lizarbe MA,et al.Bile acids in the colon,from healthy to cytotoxic molecules[J].Toxicol In Vitro,2013,27(2):964-977.
43 Kadosh E,Snir-Alkalay I,Venkatachalam A,et al.The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic[J].Nature,2020,586(7827):133-138.
44 Sun D,Chen Y,Fang J.Influence of the microbiota on epigenetics in colorectal cancer[J].National Science Review,2019,6(6):1138-1148.
45 Williams MD,Xian L,Huso T,et al.Fecal metabolome in hmga1 transgenic mice with polyposis:evidence for potential screen for early detection of precursor lesions in colorectal cancer[J].J Proteome Res,2016,15(12):4176-4187.
46 Le Gall G,Guttula K,Kellingray L,et al.Correction:metabolite quantification of faecal extracts from colorectal cancer patients and healthy controls[J].Oncotarget,2019,10(17):1660.
47 Yachida S,Mizutani S,Shiroma H,et al.Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer[J].Nat Med,2019,25(6):968-976.
48 Villéger R,Lopès A,Veziant J,et al.Microbial markers in colorectal cancer detection and/or prognosis[J].World J Gastroenterol,2018,24(22):2327-2347.

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New progress in the regulation of colorectal cancer by metabolites derived from gut microbiota

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