Abstract: Objective The aim of this study was to analyze the prevalence of high-risk population of "five cancers"(lung cancer,liver cancer,upper gastrointestinal cancer,colorectal cancer and breast cancer)of permanent residents in Baoan district,Shenzhen,so as to better carry out early prevention,early diagnosis and early treatment work of high-risk populations. Methods The risk assessment model of high-risk groups(provided by the National Cancer Center)was used to evaluate the high-risk groups with five cancers at the initial screening,and the high-risk groups were further clinically examined. Results From 2017 to 2019,a total of 6072 cases were completed.The overall high-risk rate of cancer was 55.55%.The high-risk rates of lung cancer,liver cancer,upper gastrointestinal cancer,colorectal cancer and female breast cancer were 13.87%,19.60%,25.76%,15.27and 29.77%,respectively.The high-risk rates of single cancer species,two cancer species,three cancer species,four cancer species and five cancer species were 31.35%,15.47%,6.19%,2.08% and 0.56%,respectively.The high-risk rates of lung cancer,upper gastrointestinal cancer and colorectal cancer were higher in men than in women,and the differences were statistically significant(P＜0.05).Lung cancer,upper gastrointestinal and colorectal cancer had a higher risk rate among people aged 50~69 years old,and liver cancer and female breast cancer had higher risk rates among people aged 40~69 years old,especially between 40-49 years old highest(P＜0.01).The detection rate of suspected lung cancer was 3.16%,the positive rate of liver occupation was 22.45%,the positive rate of upper gastrointestinal polyps was 22.09%,the detection rate of colorectal cancer was 0.33%,and detection rates of breast BI-RADS3 and BI-RADS4 were 17.62% and 0.82%,respectively. Conclusion This analysis has initially revealed the high-risk rate of the 5 types of cancer population in Baoan district,Shenzhen,and clarified the indicators such as clinical screening compliance and detection rate,providing theoretical reference for further optimization of population cancer screening and early diagnosis and treatment.

Key words: 40~74 years old, Lung cancer, Liver cancer, Upper digestive tract cancer, Colorectal cancer, Breast cancer, Screening, Prevalence