LncRNA-SChLAP1在结直肠癌组织中高表达的预后评估意义

doi:10.11904/j.issn.1002-3070.2020.05.007

Abstract

Abstract: Objective To investigate the effect of long-chain non-coding RNA-SChLAP1 overexpression on the prognosis of colorectal cancer(CRC).Methods A total of 156 CRC patients and 43 adjacent colorectal tissue of CRC were selected for qRT-PCR.The correlation between SChLAP1 expression and the clinicopathological characteristics,overall survival(OS),disease-free survival(DFS),and risk factors for OS and DFS in CRC patients were evaluated.Results The level of SChLAP1 in CRC was significantly higher than that in adjacent colorectal tissues,and the differences were statistically significant(P＜0.01).The high expression of SChLAP1 was related to the differentiation and stage of CRC,DFS and OS(P＜ 0.01).SChLAP1 expression was an independent risk factor for the OS and DFS of CRC patients.Conclusion SChLAP1 plays an important role in the progression of CRC.SChLAP1 may be used as an independent biomarker for the prognosis of CRC

Key words: LncRNA, SChLAP1, Colorectal cancer, Prognosis, Survival analysis

CLC Number:

R735.3

SUN Xiaoyan, ZHANG Xiaoyan. Prognostic significance of lncRNA-SChLAP1 high-expression in colorectal cancer[J]. Journal of Practical Oncology, 2020, 34(5): 425-429.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2020.05.007

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2020/V34/I5/425

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Prognostic significance of lncRNA-SChLAP1 high-expression in colorectal cancer

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