Copine-8在胃癌组织中的表达与临床病理特征及预后的相关性

doi:10.11904/j.issn.1002-3070.2020.05.008

Abstract

Abstract: Objective The aim of this study was to investigate the correlation between the expression of copine-8(CPNE8)and clinicopathological characteristics and prognosis of gastric cancer.Methods A total of 144 patients with gastric cancer who underwent radical gastrectomy in the Affiliated Hospital of Xiantao Vocational College and confirmed by pathology from March 2011 to March 2014 were collected.The expression of CPNE8 in gastric cancer and its matched adjacent tissues were analyzed by immunohistochemistry,and its relationship with clinicopathological parameters and prognosis of gastric cancer was analyzed.Results Immunohistochemical results showed that the positive expression rate of CPNE8 in gastric cancer tissues was significantly higher than that in adjacent tissues(63.9% vs. 26.4%;χ²=36.450,P＜0.0001).The expression of CPNE8 is closely related to the TNM stage and lymph node metastasis in patients with gastric cancer(χ²=5.993,P=0.014;χ²=6.703,P=0.009).Kaplan-Meier survival analysis showed that the overall survival time(OS)and disease-free survival time(DFS)of patients with high expression of CPNE8 were significantly shorter than those with low expression of CPNE8(χ²=23.130,P＜0.001;χ²=21.570,P＜0.001).The TNM stage(HR=1.297,95% CI:1.018~1.652,P=0.036),lymph node metastasis(HR=1.340,95% CI:1.027~1.749,P=0.031)and the expression of CPNE8 protein(HR=1.531,95% CI:1.208~1.940,P＜0.001)were independent risk factors influencing OS of gastric cancer patients.The TNM stage(HR=1.280,95% CI:1.028~1.593,P=0.027)and the expression of CPNE8 protein(HR=6.010,95% CI:1.355~26.661,P=0.018)were independent risk factors for DFS of gastric cancer patients.Conclusion The expression of CPNE8 is significantly up-regulated in gastric cancer tissues,and is closely related to the malignant pathological characteristics of patients.CPNE8 may be one of the prognostic markers for gastric cancer patients.

Key words: Copine-8, Gastric cancer, Clinicopathological features, Prognosis

CLC Number:

R735.2

YIN Songxiang. Expression of Copine-8 in gastric cancer and its correlations with clinicopathological features and prognosis[J]. Journal of Practical Oncology, 2020, 34(5): 430-435.

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References

1 Siegel RL,Miller KD,Jemal A.Cancer statistics,2019[J].CA Cancer J Clin,2019,69(1):7-34.
2 周家琛,郑荣寿,庄贵华,等.2000-2015年中国肿瘤登记地区胃癌发病趋势及年龄变化[J].实用肿瘤学杂志,2020,34(1):1-5.
3 Karimi P,Islami F,Anandasabapathy SA,et al.Gastric cancer:descriptive epidemiology,risk factors,screening,and prevention[J].Cancer Epidemiol Biomarkers Prev,2014,23(5):700-713.
4 Song ZY,Wu YY,Yang JB,et al.Progress in the treatment of advanced gastric cancer[J].Tumour Biol,2017,39(7):1010428317714626.
5 Necula L,Matei L,Dragu D,et al.Recent advances in gastric cancer early diagnosis[J].World J Gastroenterol,2019,25(17):2029-2044.
6 Perestenko PV,Pooler AM,Noorbakhshnia M,et al.Copines-1,-2,-3,-6 and -7 show different calcium-dependent intracellular membrane translocation and targeting[J].FEBS J,2010,277(24):5174-5189.
7 Tomsig JL,Snyder SL,Creutz CE.Identification of targets for calcium signaling through the copine family of proteins.Characterization of a coiled-coil copine-binding motif[J].J Biol Chem,2003,278(12):10048-10054.
8 Dang TT,Westcott JM,Maine EA,et al.ΔNp63α induces the expression of FAT2 and Slug to promote tumor invasion[J].Oncotarget,2016,7(19):28592-28611.
9 Buccilli MJ,Ilacqua AN,Han M,et al.Copine a interacts with actin filaments and plays a role in chemotaxis and adhesion[J].Cells,2019,8(7):758.
10 张昭颖,李游,游金,等.兔抗人copine-8蛋白多克隆抗体的制备[J].细胞与分子免疫学杂志,2018,34(5):456-461.
11 Maitra R,Grigoryev DN,Bera TK,et al.Cloning,molecular characterization,and expression analysis of Copine 8[J].Biochem Biophys Res Commun,2003,303(3):842-847.
12 Ilacqua AN,Price JE,Graham BN,et al.Cyclic AMP signaling in Dictyostelium promotes the translocation of the copine family of calcium-binding proteins to the plasma membrane[J].BMC Cell Biol,2018,19(1):13.
13 Ramsey H,Zhang DE,Richkind K,et al.Fusion of AML1/Runx1 to copine VIII,a novel member of the copine family,in an aggressive acute myelogenous leukemia with t(12;21)translocation[J].Leukemia,2003,17(8):1665-1666.
14 Bu D,Lewis CM,Sarode V,et al.Identification of breast cancer DNA methylation markers optimized for fine-needle aspiration samples[J].Cancer Epidemiol Biomarkers Prev,2013,22(12):2212-2221.
15 Nagasawa S,Ikeda K,Horie-Inoue K,et al.Systematic identification of characteristic genes of ovarian clear cell carcinoma compared with high-grade serous carcinoma based on RNA-sequencing[J].Int J Mol Sci,2019,20(18):4330.
16 Liu J,Wang P,Zhang P,et al.An integrative bioinformatics analysis identified miR-375 as a candidate key regulator of malignant breast cancer[J].J Appl Genet,2019,60(3/4):335-346.

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Expression of Copine-8 in gastric cancer and its correlations with clinicopathological features and prognosis

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