Abstract: Objective The study aimed to investigate the clinicopathological features of patients with bone metastasis from gastric cancer and to screen the independent prognostic factors.Methods The clinical data of 157 patients with bone metastasis from gastric cancer in Zhongnan Hospital of Wuhan University from April 2007 to December 2013 was retrospectively analyzed.Results The median time from diagnosis of gastric cancer to bone metastasis was 280.5 days in 157 patients with gastric cancer.There were 124 cases of multiple bone metastases and 22 cases of single bone metastasis.The most common sites of bone metastasis were the spine(88.5%),the pelvis(51.6%)and the ribs(51.0%).Many patients were accompanied by extra-organic metastasis(78.3%).The pathological differentiation of gastric cancer patients with bone metastasis was mostly poor,with poorly differentiated adenocarcinoma(69.3%)and signet ring cell or mucinous adenocarcinoma(33.1%).The median survival time after gastric metastasis in gastric patients was 109 days.Univariate analysis showed that the levels of CEA and LDH,hemoglobin concentration,albumin concentration,extra-osseous metastasis,systemic chemotherapy and bisphosphonate treatment were associated with prognosis of patients with bone metastasis from gastric cancer(P＜0.05).Multivariate analysis showed that the CEA level with extra-osseous metastasis,systemic chemotherapy and bisphosphonate treatment were independent prognostic factors.Conclusion Elevated CEA and extra-osseous metastasis are independent prognostic factors.Chemotherapy and bisphosphonate therapy may improve the prognosis of patients.

Key words: Gastric cancer, Bone metastasis, Clinical pathology, Prognosis