放疗延迟对乳腺癌不同分子亚型患者预后的影响

doi:10.11904/j.issn.1002-3070.2019.05.009

Abstract

Abstract: Objective The aim of this study was to investigate the effect of delayed radiotherapy on the prognosis of breast cancer patients with different molecular subtypes.Methods A total of 341 patients with radical mastectomy were enrolled in our hospital from January 2007 to December 2012.There were 149 patients with Luminal A type,83 patients in the control group,and 66 patients in the delayed radiotherapy group.There were 105 cases with Luminal B type,63 cases of control group and 42 cases of delayed radiotherapy.There were 43 cases of HER2+,28 cases of control group and 15 cases of delayed radiotherapy.There were 44 patients with triple-negative,27 cases in the control group,and 17 patients in the delayed radiotherapy group.Analyzed the difference in progposis betueen the delayed radiotherapy group and the contrel group.Results The local recurrence rate of Luminal A,Luminal B,HER2+ and triple negative type in the control group and the delayed radiotherapy group were(4.8% vs. 9.1%,P=0.301),(4.7% vs. 19.0%,P=0.019),(7.1% vs. 33.3%,P=0.027),(11.1% vs. 35.3%,P=0.053),respectively;distant metastasis rate:(9.6% vs. 10.6%,P=0.8 45),(11.1% vs. 14.2%,P=0.234),(32.1% vs. 40.0%,P=0.937),(37.0% vs. 41.2%,P=0.784),respectively;tumor-free survival rate:(85.5% vs. 80.3%,P=0.395),(84.1% vs. 66.7%,P=0.037),(60.7% vs. 33.3%,P=0.087),(55.5% vs. 23.5%,P=0.037),respectively;overall survival rate:(94.0% vs. 90.9%,P=0.539),(84.1% vs. 80.9%,P=0.672),(67.9% vs. 60.0%,P=0.606),(59.2% vs. 41.2%,P=0.242),respectively.Cox regression analysis showed that tumor size(HR=3.156,P=0.043),lymph node metastasis(HR=1.074,P=0.001),TNM(HR=8.591,P=0.009)and molecular subtype(HR=2.092,P＜0.001)were independent factors influencing prognosis of breast cancer patients.Conclusion The local recurrence rate of Luminal B type and HER2+ is significantly increased due to delayed radiotherapy.The disease-free survival rates of Luminal B type and triple negative type are significantly increased reduced due to delayed radiotherapy.Tumor size,lymph node metastasis,TNM staging and molecular subtypes are independent risk factors for patient survival.

Key words: Breast cancer, Radio therapy, Molecular typing

CLC Number:

R737.9

SHI Manru, E Mingyan. Effect of delayed radiotherapy on the prognosis of patients with different molecular subtypes of breast cancer[J]. Journal of Practical Oncology, 2019, 33(5): 431-435.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2019.05.009

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2019/V33/I5/431

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Effect of delayed radiotherapy on the prognosis of patients with different molecular subtypes of breast cancer

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