FOXD3在肺癌细胞中的作用

doi:10.11904/j.issn.1002-3070.2019.05.002

Abstract

Abstract: Objective The aim of this study was to explore effects of FOXD3 on proliferation and migration of lung cancer A549 cells.Methods The expression of FOXD3 in various tumors was analyzed in the TCGA database.The online database GEPIA was used to assess the prognostic impact of FOXD3 mRNA expression.FOXD3 overexpressing lung cancer cell line was constructed and functional assay was performed to detect the role of FOXD3 in lung cancer cells.The STRING database was used to predict the regulatory network in which FOXD3 is involved.Results By comparing the expression profiles of tumors,among them,FOXD3 is up-regulated in tumors with skin cutaneous melanoma(SKCM),and FOXD3 is down-regulated in tumors:colon adenocarcinoma(COAD),rectal adnocarcinoma(READ)and testicular germ cell tumor(TGCT).Through the using of the GEPIA database to study the survival of cancer patients,FOXD3 was found to have an impact on the overall survival of patients with lung squamous cell carcinoma(LUSC),SKCM,adrenocortical carcinoma(ACC),and lower grade glioma(LGC).FOXD3 could inhibit the proliferation and migration of lung cancer cells.FOXD3 could be involved in the regulation of expression of various genes by using the STRING database.Conclusion FOXD3 overexpression inhibits proliferation and migration of lung cancer cells is closely associated with the prognosis of patient.Therefore,FOXD3 can be a good indicator for indicating good prognosis of lung cancer and provide new ideas for cancer treatment.

Key words: FOXD3, Lung cancer, Prognosis

CLC Number:

R734.1

LIU Siwei, CUI Yue, SUN Yuanyuan, HU Jing, ZHANG Wenrui, CAO Mengru. Effect of FOXD3 in lung cancer cells[J]. Journal of Practical Oncology, 2019, 33(5): 390-396.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2019.05.002

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2019/V33/I5/390

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Effect of FOXD3 in lung cancer cells

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