RRBP1与RABEX-5蛋白在结直肠癌组织中的表达及与临床病理特征和预后的关系

doi:10.11904/j.issn.1002-3070.2020.01.008

Abstract

Abstract: Objective The aim of this study was to investigate the expression of ribosomal binding protein 1(RRBP1)and RABEX-5 proteins in colorectal cancer and their correlation with clinicopathological features and prognosis.Methods Colorectal cancer tissue specimens and paracancerous tissue specimens from 86 patients with colorectal cancer who underwent surgical treatment were collected from August 2015 to August 2016.Immunohistochemical staining was used to detect the levels of RRBP1 and RABEX-5 proteins.The relationship between the expression of RRBP1 and RABEX-5 protein and clinicopathological features of patients with colorectal cancer was analyzed.Cox proportional hazard analysis was used to analyze the associated factors of colorectal cancer patients affecting prognosis.Results The positive expression rates of RRBP1 and RABEX-5 proteins in colorectal cancer tissues were 65.12% and 62.79%,respectively.The positive expression rates of RRBP1 and RABEX-5 proteins in colorectal adjacent tissues were 38.37% and 36.05%,respectively.There were significant differences in the positive expression rates of RRBP1 and RABEX-5 proteins(P＜0.001).The positive expression rates of RRBP1 and RABEX-5 in colorectal cancer patients with stage Ⅲ-Ⅳ TNM,poor tumor differentiation and lymphatic metastasis were increased(P＜0.05).The median overall survival time of RRBP1 positive and negative expression was 30 months and 20 months,respectively.The median overall survival time of RABEX-5 positive and negative expression was 31 months and 19 months,respectively.The results of univariate and multivariate analyses showed that TNM stage Ⅲ-Ⅳ,tumor subdivision,lymphatic metastasis,RRBP1 positive expression and RABEX-5 positive expression were independent factors affecting the prognosis of patients with colorectal cancer(P＜0.01).Conclusion The levels of RRBP1 and RABEX-5 proteins in colorectal cancer tissues are increased,positively correlated with TNM stage and lymphatic metastasis of colorectal cancer patients,and negatively correlated with the degree of differentiation.The positive expression of RRBP1 and RABEX-5 proteins is a risk factor for the prognosis of colorectal cancer patients,and they can be used as effective biomarkers for diagnosis and prognosis of colorectal cancer.

Key words: RRBP1, RABEX-5, Colorectal cancer, Clinicopathological features, Prognosis

CLC Number:

R735.3

LIAO Daixiang, ZHENG Bo, ZHANG Yanbin, YU Junhui. Expression of RRBP1 and RABEX-5 proteins in colorectal cancer and their correlation with clinicopathological features and prognosis[J]. Journal of Practical Oncology, 2020, 34(1): 43-48.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2020.01.008

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2020/V34/I1/43

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Expression of RRBP1 and RABEX-5 proteins in colorectal cancer and their correlation with clinicopathological features and prognosis

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