Abstract: Objective The aims of this study were to analyze the trend of colorectal cancer death level and the probability of premature death caused by colorectal cancer in Jinshan district,Shanghai from 1980 to 2018,and to provide a basis for formulating prevention and control strategies and measures of colorectal cancer.Methods The death cases of colorectal cancer were collected in Jinshan district from 1980 to 2018 through the cause registration information system.The colorectal cancer crude mortality in different periods,standardized mortality,age group mortality,early death probability and annual change percentage were calculated.Results From 1980 to 2018,the crude mortality of colorectal cancer in Jinshan district showed an upward trend(APC=2.41%,P＜0.001),and the standardized mortality showed a downward trend(APC=-1.21%,P＜0.001).During 39 years,the mortality of colorectal cancer in the 30~69 years old group did not increase or decrease in men(APC=-0.73%,P=0.070),and the decline in women(APC =-1.80%,P＜0.001).However,there was no obvious upward and downward trend in women colorectal cancer between 2000—2009 and 2010—2018(APC=-3.36%,2.19%,P=0.266,0.465).During 39 years,the probability of early death of male colorectal cancer showed a downward trend(APC=-1.71%,P＜0.001),but there was no obvious upward and downward trend between 2000—2009 and 2010—2018(APC=-2.90%,-2.36%,P=0.150,0.286).During the same period,the probability of early death in female colorectal cancer patients showed a downward trend(APC=-1.96%,P＜0.001),and there was no obvious upward and downward trend between 2000—2009 and 2010—2018(APC=-5.70%,0.19%,P=0.075,0.946).Conclusion Colorectal cancer is one of the most serious malignant tumors threatening the health of residents in Jinshan district.Since 2000,the standardized mortality and early death probability of colorectal cancer in men and women have not shown a significant downward trend.Targeted health interventions and public health policies should be adopted to reduce colorectal cancer mortality and premature death.

Key words: Colorectal cancer, Mortality, Early death probability, Trend