Abstract: Gastric cancer(GC)is a complex heterogeneous disease with high morbidity and mortality all year round.Molecular targeted therapy is expected to become a more effective treatment strategy with limited or nonexistent side effects on normal cells of the body.Wingless-Type MMTV Integration Site Family/beta-catenin(β-catenin)(Wnt for short)signaling pathway is involved in the regulation of embryoic development and cell proliferation,differentiation,migration,apoptosis and so on.It is one of the main pathways involved in the occurrence,progression and metastasis of cancer.Dysregulation of the Wnt pathway is observed in approximately 50% of GC patients and thus may provide a new therapeutic target.In recent years,more and more evidence has shown that the Wnt pathway plays a central role in the occurrence and progression of GC,and some inhibitors targeting this pathway at the ligand/receptor level are being studied in preclinical or clinical trials.Finding new useful targets may become a potential marker for early diagnosis and treatment of GC.This article reviews the relationship between Wnt signaling pathway and GC,and the research progress of the pathway inhibitors in GC,in order to provide a new strategy for the diagnosis and treatment of GC.

Key words: Gastric cancer, Wnt/β-catenin signaling pathway, Inhibitor