Abstract: Objective This study aimed to observe the survival and progress of patients with cervical cancer,and to explore its influencing factors,so as to provide evidence for improving the prognosis.Methods A total of 2 306 cervical cancer patients hospitalized in Harbin Medical University Cancer Hospital between January 2013 and December 2015 were included for reviewed and followed up.The Kaplan-Meier method was used to analyze the overall survival and progression-free survival of cervical cancer patients.The Cox risk proportional regression model was used to analyze the influencing factors of survival.Results The 5-year survival rates of stage Ⅰ,Ⅱ,Ⅲ and Ⅳ patients were 87.3%,79.3%,61.8%,and 36.8%,respectively;the 5-year progression-free survival rates were 82.9%,73.0%,55.6%,and 0,respectively.The median follow-up time was 51.0 months.Univariate analysis showed that the age of diagnosis,menopausal status,the number of births,history of heart disease,the history of abortion,lymph node status,vascular cancer thrombus,FIGO staging,mentality,diet status,and age of final delivery,etc.were related to the patient's OS and PFS.Multivariate analyses showed that age at final delivery,lymph node status,vascular tumor thrombus and the degree of interstitial invasion were independent factors that affected the OS and PFS.Conclusion In addition to pathological features,multiple pregnancy,multiple births,and older age at final delivery are risks factors for poor prognosis of the patients with cervical cancer.

Key words: Cervical cancer, Follow-up, Overall survival, Progression-free survival, Comparative study of efficacy