Journal of Practical Oncology ›› 2020, Vol. 34 ›› Issue (5): 446-450.doi: 10.11904/j.issn.1002-3070.2020.05.011

• Review • Previous Articles     Next Articles

Research progress of lncRNA SNHGs in the occurrence and development of prostate cancer

MIAO Pengcheng, KANG Yindong, LI Fudong, MENG Dongdong, WANG Dongxing, CHANG Dehui   

  1. Department of Urology,The 940th Hospital of Joint Logistics Support Force of Chinese People′s Liberation Army,Lanzhou 730050,China
  • Received:2020-03-04 Online:2020-10-28 Published:2020-11-02

Abstract: Prostate cancer has become a global“killer”that threatens the health of elderly men.The mechanism and treatment of its occurrence and development are the current research focuses.In recent years,gene transcription or post-transcriptional regulatory mechanisms have been shown to play a key role in the progression of prostate cancer,of which long non-coding RNA(lncRNA)plays an important role.lncRNA SNHGs are closely related to prostate cancer.They not only affect the biological characteristics of tumors,playing a vital role in the apoptosis,autophagy,invasion,and cell proliferation of prostate cancer cells,but they also are related to tumor prognosis.Its mechanism of action is related to ceRNA,Wnt/β-catenin,PI3K/AKT/mTOR and other signaling pathways.This article reviews the role of LncRNA SNHGs in the occurrence and development of prostate cancer,hoping to provide new ideas for the diagnosis and treatment of prostate cancer.

Key words: Long non-coding RNA, Prostate cancer, Competitive endogenous RNA

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