LncRNAs作为ceRNAs在肺癌中的研究进展

doi:10.11904/j.issn.1002-3070.2020.05.012

Abstract

Abstract: Long non-coding RNAs(lncRNAs)is a type of noncoding RNAs with a length of 200~100,000bp,and the protein coding ability is lacking or limited.Recent studies have shown that it can participate in tumor cell proliferation,apoptosis,migration and invasion through the mechanism of competing endogenous RNAs(ceRNAs),and plays an important regulatory role in the development of tumors.Lung cancer is one of the malignant tumors with the highest morbidity and mortality,hich is a serious threat to population health and life safety.Therefore,this paper reviews the regulatory mechanism of lncRNAs as members of ceRNAs network in lung cancer to provide the basis for diagnosis and treatment of lung cancer.

Key words: Long non-coding RNAs, Competitive endogenous RNAs, Micro RNAs, Lung cancer

CLC Number:

R734.2

CHENG Yue, ZHANG Mingyan, ZHANG Wenbo, XU Hui. Research progress of lncRNAs as members of ceRNAs networks in lung cancer[J]. Journal of Practical Oncology, 2020, 34(5): 451-455.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2020.05.012

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2020/V34/I5/451

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Research progress of lncRNAs as members of ceRNAs networks in lung cancer

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