Abstract: Objective The Objective of this study was to investigate the effect of ketorolac tromethamine on preventive analgesia in the immune function of patients with lung cancer surgery.Methods A total of 172 patients with lung cancer surgery in our hospital from September 2017 to September 2019 were selected and divided into the prevention group and general anesthesia group according to the random number table.Each group had 86 cases.The general anesthesia group was given general anesthesia intervention.The prevention group was given ketorolac tromethamine as the preventive analgesia.On the basis,the mean arterial pressure(MAP),heart rate(HR),visual analogue scale(VAS),immune globulin(IgA,IgG,and IgM)and T lymphocyte subsets(CD3⁺,CD4⁺,and CD4⁺/CD8⁺)and adverse reaction were compared between the prevention and general anesthesia groups.Results The MAP and HR in the prevention group at 15 min after anesthesia(T₁),tissue incision(T₂),tumor resection(T₃)were significantly lower than those in the general anesthesia group,the difference was statistically significant(P＜ 0.001).The levels of IgA,IgG,IgM,CD3⁺,CD4⁺,and CD4⁺/CD8⁺ in the prevention group after operation were significantly higher than those in the general anesthesia group,the difference was statistically significant(P＜ 0.001).The VAS scores in the prevention group at 4 h,24 h,48 h and 72 h were significantly lower than that in the general anesthesia group,the difference was statistically significant(P＜ 0.001).There was no significant difference in the incidence of adverse reactions between the prevention and general anesthesia groups(P＞0.05).Conclusion Preventive analgesia with ketorolac tromethamine can effectively improve the hemodynamic fluctuations and analgesic effect on patients with lung cancer surgery,and it is beneficial to improve the immune function of patients.It has good safety and worth for further clinical application.

Key words: Ketorolac tromethamine, Preventive analgesia, Lung cancer surgery, Immune function