Abstract: Objective To study the treatment influences on immunity and tumor recurrence of oral cancer patients with the combination therapy of hyperbaric oxygen treatment and postoperative adjuvant chemotherapy.Methods In the period from March 2011 to March 2014,84 patients were clearly diagnosed with oral cancer and randomly divided into hyperbaric oxygen treatment combined postoperative adjuvant chemotherapy group(group A,n=42)and postoperative adjuvant chemotherapy group(group B,n=42).From day 1 prior to the last day of chemotherapy,patients in group A were treated with hyperbaric oxygen,and patients in group B were just accepted chemotherapy.After chemotherapy,we tested the levels of CD3⁺,CD4⁺,CD8⁺ and NK cells by flow cytometry,and the expression of IL-2,IL-4,IL-10 and INF-γ by ELISA essay.All patients had been followed for two years.Results The levels of CD4⁺ and NK cells in group A were higher than group B(P＜0.05),but the levels of CD3⁺ and CD8⁺between the two groups were obviously different(P＞0.05).Compared with group B,the ratio of CD4⁺and CD8⁺ was increased in group A(P＜0.05).The levels of cytokines involved IL-2,IL-4,IL-10 and INF-γin group A were higher than the levels of group B(P＜0.05).Follow-up results showed that patients treated with hyperbaric oxygen combined postoperative adjuvant chemotherapy had less recurrence in 2 years(P＜0.05).Conclusion Hyperbaric oxygen combined postoperative adjuvant chemotherapy can improve the patients′ immune function,and to be effective in preventing two years′ recurrence.

Key words: Oral cancer, Hyperbaric oxygen, Post-operative adjuvant chemotherapy, Immune function