Abstract: Liver cancer is the main source of the global cancer burden,and the most important histological type of liver cancer is hepatocellular carcinoma(HCC).Therefore,elucidating the mechanism of HCC occurrence,development,recurrence and finding new therapeutic targets have become an important direction of HCC research.In recent years,more and more scholars have studied the synthesis of glucosyl phosphatidylinositol(GPI)anchored proteins,and found that the abnormal expression of multiple subunits involved in the synthesis of GPI-anchored proteins is not only involved in the development of human disease,but also participated in the occurrence and development of a variety of human tumors.Glycosylphosphatidylinositol transamidase(GPI-T),consisting of five subunits,acts as a key enzyme for protein transfer to GPI anchors.PIGU was introduced in 2004.It was proved to be involved in the occurrence and development of bladder cancer for the first time,and then its five subunits were gradually confirmed to be involved in the occurrence and development of HCC.In this paper,five subunits of GPIT involved in the pathogenesis and development of HCC were reviewed.

Key words: Glycosylphosphatidylinositol transamidase, Hepatocellular carcinoma, Phosphatidylinositol glycan anchoring biosynthesis class