PRACTICAL ONCOLOGY JOURNAL ›› 2009, Vol. 23 ›› Issue (6): 520-523.doi: 10.3969/j.issn.1002-3070.2009.06.006

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Study on effect of hepatocytes transplantation in rats with acute liver failure

SUN Dawei1, ZHANG Songyan1, HAO Jun2, LI Haiyang3   

  1. 1.Department of Abdominal Surgery, The Affiliated Tumor Hospital of Harbin Medical University, Harbin 150081;
    2.Health Department of Heilongjiang Province;
    3.Department of Hepatobiliary Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang 550004
  • Received:2009-08-26 Online:2009-12-25 Published:2012-02-21

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Abstract: Objective To study the effect of hepatocyte transplantation(HCT)intraperitoneal in rats with acute liver failure(ALF)which were induced by D-galactosamineN, and to discuss whether this is an effective way.Methods ALF animals were induced by D-GalN.HCT was received 48h after intoxication.GroupⅠreceived 2.5×107hepatocytes intraperitoneally.GroupⅡreceived 2.5mL NS intraperitoneally.The survival rates, liver function, liver histology and biologic characteristics of transplanted cells were assessed.Survival rate of groupⅠwas much higher than that of groupⅡ(54.2% vs 8.3%, P＜0.005), the liver function and liver histology were partially improved in groupⅠas compared with groupⅡ.Conclusion Survival rate of ALF rats intoxicated with D-GalN could be improved, the liver function and liver histology could also be partially improved, via intraperitoneal HCT.

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