PRACTICAL ONCOLOGY JOURNAL ›› 2010, Vol. 24 ›› Issue (6): 512-514.doi: 10.3969/j.issn.1002-3070.2010.06.003

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The expression of serous angiopoietin and its affeoh in hepatocellular carcinoma

ZHANG Pengyu1, LI Yuanyuan2, LI Mingqi3, SHI Xuekui2, TAO Ji3, XIAO Lin1, WANG Yaxian2   

  1. 1.Department of Clinical Laboratory,Key Laboratory of Cancer Prevention and Therapy,Tianjin Medical University Cancer Institute and Hospital,TianJin 300060;
    2.Department of Microbiology and Immunology,Heilongjiang University of Traditional Chinese Medicine;
    3.The Third Affiliated Hospital of Harbin Medical University
  • Received:2010-06-30 Online:2010-12-28 Published:2015-01-24

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Abstract: Objective To investigate the clinical significance of serous angiopoietin-2(Ang-2)in hepatocellular carcinoma(HCC)and the feasibility of using it as a diagnostic indicator.Method The serous Ang-2 level in 30 hepatocellular carcinoma patients,10 cirrhosis patients as well as 10 health controls was detected with enzyme linked immunosorbent assay(ELISA).Result The Ang-2 level of cirrhosis group(1244.21±14.65)μg/L was higher than that of control group(943.01±12.52)μg/L,while the level of HCC group(1892.54±482.82)μg/L was higher than that of both cirrhosis group and control group;HCC group had higher level of AFP(4397.61±613.82)μg/L,CA199(64.88±10.71)U/mL,FERR(401.53±51.32)μg/L and CEA(4.69±1.00)μg/L than that of control group(P＜0.05);the patients of HCC group complicated with cirrhosis also had higher level of Ang-2(2045.41±155.31)μg/L,AFP(5097.17±2830.22)μg/L,CA199(67.53±9.35)U/mL,FERR(462.87±56.79)μg/L and CEA(5.41±2.25)μg/L than those without cirrhosis(P＜0.05).Conclusion The elevated Ang-2 is relevant to the pathogenesis and advancement of HCC,while serous Ang-2 is a promising candidate tumor marker for the diagnosis of HCC.

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