PRACTICAL ONCOLOGY JOURNAL ›› 2011, Vol. 25 ›› Issue (6): 525-527.doi: 10.3969/j.issn.1002-3070.2011.06.007

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Effects of IL-24 on cytotoxic activity of cytokine-induced killer cells in vivo

YUAN Yutao1,LIANG Xiaoliang1,ZHANG Jing1,HUANG Lianjiang1,WANG Zhihua2   

  1. 1.Department of Laboratory,No.2 Hospital Ximen,Ximen 361026;
    2.Cancer Institute of Heilongjiang Province,Harbin 150081
  • Received:2011-07-18 Online:2011-12-28 Published:2014-12-02

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Abstract: Objective To study the effects of IL-24 on cytotoxic activity of cytokine-induced killer cells in vivo.Methods (1)Mononuclear cells were extract from health adult peripheral blood.one group added IFN-γ(1000IU/mL)at the first day and IL-1(100IU/mL)、CD3mAb(50ng/mL)、IL-2(300IU/mL)at the second day.The other group added IL-24(1000IU/mL)at the same time with IL-1、CD3mAb、IL-2;(2)Tumor-bearing mice were divided into five groups,and tumor volumes were measured every three days.Results The solid tumor volumes of IL-24 induced group are smaller than other groups(P＜0.05).Conclusion Added IL-24 during induced procedure can obviously enhance the cytotoxic activity of CIK cells in vivo.

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