Abstract: Objective To explore the value and treatment effect of renal TACE,excision and immunotherapy combination therapy of large renal carcinoma in middle-advanced stage. Methods Before the treatment,patients were examined,patients stages were confirmed,and suitable cases were chosen.The 22 patients in combined treatment group first underwent renal carcinoma TACE with chemotherapy emulsion like gemcitabine,etc.Three to seven days later,all these patients had the radical nephrectomy.Three days after the radical operation,IL-2 immunotherapy was performed on 22 patients.The 23 patients in the surgery group merely underwent radical nephrectomy.Perioperative blood transfusion,operation time,3-year-overall survival and 5-year-overall survival of the two groups have been compared.Results In combined treatment group,2 cases of arteriovenous fistula and 2 cases of abnormal blood supply were found in the course of renal carcinoma TACE.In surgery group,two patients had adhesion of inferior vena cava(IVC)tumor thrombus and vessel wall,whose cancer thrombus could not be completely resected.One patient died of pulmonary infarction during the operation.Perioperative blood transfusion,operation time,3-year-overall survival and 5-year-overall survival of the combined treatment group are 409.45mL,122.27min,72.7% and 63.6%;717.39mL,171.82min,43.5% and 33.3% of the surgery groups,respectively.Compared with the two sets of data by SPSS,we found that each was P＜0.005.It is which showed that the difference between the two groups has statistics significance.Conclusion Renal TACE,excision and immunotherapy combination of large renal carcinoma in middle-advanced stage can make the following benefits possible:decreasing operation risks,reducing perioperative blood transfusion,shortening operation time and increasing 3-year-overall survival and 5-year-overall survival in those patients.