Abstract: Objective To study the expression and significance of coagulation and fibrinolysis indexes in lung caner patients with different pathology types、stages and therapeutic states.Method The plasma levels of platelet(PLT),prothrobin time(PT),activated partial thromboplastin time(APTT),throbin time(TT),D-dimer(D-D),fibrinogen(FIB),tissue type plasminogen activator(tPA) and urokinase type plasminogen activator(uPA)and urokinase plasminogen activator receptor(uPAR)were measured by ELLISA technique in 62 lung cancer patients before and after therapy.Result The levels of PLT,PT,APTT,TT were no difference in all kinds of patients(P＞0.05).The levels of FIB were significantly higher in patients with Ⅳ stage and small cell lung cancer(SCLC)than those in other stages and types (P=0.028 and P=0.005,respedida)and 0.005 and the differences have statistical significance.The level of D-D was higher in adenocarcinoma than those in other types(P=0.005).The level of uPAR was lower in adenocarcinoma than those in other types and higher in Ⅲ stage patients than Ⅳ stage,bat the uPAR levels of patients who received operation and chemotherapy were lower than those not receiving any therapy (P=0.03,P=0.045 and P=0.007,respedively).The tPA level was higher in SCLC than those in other types(P=0.04).Conclusion The plasma level of UPAR was lower in patients who received any therapy than those not.The plasma of D-dimer is higher in adenocarcinoma patients than those in other type patients;Different type and clinical stage of lung cancer expressed different coagulation and fibrinolysis factors and quantity.