Abstract: Abstract Alteration of metabolism and epigenetic status are two new focus in the field of cancer research. Recently, more and more reports have demonstrated that the changes of both metabolic enzymes and altered epigenetic status have close interrelationship with the pathogenesis and development of gliomas in human. We discuss here the effects of altered metabolic enzymes on epigenetic status in gliomas based on two important altered metabolic enzymes, with the aim to unlock the molecular mechanism of how gliomas occur and progress. This newfound molecular mechanism of how altered metabolic enzymes impact on epigenetic status in gliomas may contribute to the identification of novel therapeutic targets to gliomas in the future.

Key words: Gliomas, Metabolic enzymes, Epigenetic