Abstract: Objective Our retrospective study is aimed to analyze the correlative clinical features of between expressions of miR-135b and miR-141 in colorectal cancer.Methods Clinical data and specimens of patients with colorectal carcinoma at our hospital from 2013 to 2014 were retrospectively collected.The expressions of miR-135b and miR-141 between colon cancer and matched normal colonic tissues were compared.The correlation between the expressions of miR-135b and miR-141 in colorectal carcinoma and the clinical characteristics were discussed.Results A total of 42 patients was retrospective analyzed.The expressions of miR-135b,miR-141 in the colon cancer tissues were obviously higher than that in the normal colonic tissues.The differences of the expression of miR-141 in the colon cancer tissues of different Dukes stages,degree of differentiation,lymph node metastasis and infiltration depth were all significant.The expressions of miR-135b and miR-141 displayed a positive linear correlation.Conclusion The expressions of miR-135b,miR-141 in colorectal cancer are significantly increased,and the expressions display a remarkable correlation with the Dukes stages,degree of differentiation,lymph node metastasis and infiltration depth of tumor.The expressions of miR-135b and miR-141 demonstrate a positive correlation.