Abstract: Objective To investigate the effect of Pine Cone Extract(PCE)on the mice with transplanted S180 sarcoma.Methods On the second day after S180 sarcomas being transplanted into the right axilla of mice,the mice were divided into four groups(water control group,cyclophosphamide group,low PCE group and high PCE group)and administered water,cyclophosphamide(ip),low PCE group and high PCE by gavage for 14 days,respectively.The dose volume was 0.02mL/g body weight and once daily.Another group was used as normal control.Then indices of thymus and spleen and inhibitory rate of S180 tumor were observed.Results The indices of the thymus and spleen in the tumor PCE group had no significant difference compared with water control group.Inhibition rate of S180 sarcoma in the high PCE group compared with the control group was 46.1%.Conclusion PCE obviously inhibits the growth of S180 sarcoma with 14 days administration at suitable dosage.