Abstract: Objective To investigate the mRNA expression of tumor suppressor gene ING1 in breast carcinoma and evaluate its clinical significance.Methods Reverse transcription polymerase chain reaction(RT-PCR)was used to detect the mRNA expression of ING1 in 51 cases of breast carcinoma,30 adjacent normal tissues and 12 benign breast tumors.The relationship of ING1 mRNA expression to clinicopathological characteristics was statistically analyzed.Results (1)The expression of ING1 mRNA in breast carcinoma tissues(0.5458±0.2310)was lower than that in the adjacent normal tissues(0.6625±0.1699).The expression of ING1 mRNA in groups of breast carcinoma tissues,the adjacent normal tissues and the benign breast tumor tissues were significantly different(P＜0.05).(2)ING1 mRNA expression in breast carcinoma tissues was related with pathological type and lymph node metastasis(P＜0.05).ING1 mRNA expression in breast carcinoma tissues had no relevance with the other clinicopathological characteristics(P＞0.05).Conclusion The mRNA expression of ING1 is significant associated with tumor progression in breast carcinoma,and it may be considered as a valuable marker for the gene therapy of breast carcinoma