人端粒酶逆转录酶在肿瘤转录调控机制中的研究进展

doi:10.11904/j.issn.1002-3070.2023.01.012

Abstract

Abstract: Human telomerase reverse transcriptase(hTERT) is the core and rate-limiting component of regulating telomerase activity.It plays an important role in regulating telomere length,maintaining gene stability,and regulating the growth and development of tumor cells.At present,the research on hTERT has become a hot issue in the research of telomerase.In recent years,the study of hTERT in the transcriptional regulation mechanism of tumor transcription has been made new progress.The discovery of GA-binding protein alpha,a key factor of TERT promoter mutation,novel hTERT transcriptional regulators,and hTERT hypermethylated tumor region may provide potential new therapeutic targets.This article will review the transcriptional regulation of hTERT from promoter mutations,transcriptional regulators and epigenetic modifications,aiming to lay a theoretical foundation for hTERT-related research and the development of hTERT-targeted drugs.

Key words: Telomerase, Human telomerase reverse transcriptase, Promoter mutations, Transcriptional regulators, Epigenetic modifications

CLC Number:

R551.3

ZENG Ping, GUO Pengxiang, LUO Heng. Research progress of human telomerase reverse transcriptase in tumor transcriptional regulation mechanism[J]. Journal of Practical Oncology, 2023, 37(1): 68-72.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2023.01.012

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Research progress of human telomerase reverse transcriptase in tumor transcriptional regulation mechanism

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